Anti-SIN3B Antibody (CAB10584)
- SKU:
- CAB10584
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-SIN3B Antibody |
| 抗体コード: | CAB10584 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human SIN3B (NP_056075.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | A-431, Raji, HeLa, Mouse kidney, Mouse testis, Mouse brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human SIN3B (NP_056075.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAHA GGGS GGSG AGGP AGRG LSGA RWGR SGSA GHEK LPVH VEDA LTYL DQVK IRFG SDPA TYNG FLEI MKEF KSQS IDTP GVIR RVSQ LFHE HPDL IVGF NAFL PLGY RIDI PKNG KLNI QSPL TSQE NSHN HGDG AEDF KQQV PYKE DKPQ VPLE SDSV |
| 遺伝子ID: | 23309 |
| Uniprot: | O75182 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 39kDa/129kDa/133kDa |
| 観察された分子量: | 133kDa |
| 同義語: | SIN3B |
| バックグラウンド: |
| UniProt Protein Function: | SIN3B: Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 19p13.11 Cellular Component: nucleoplasm; nucleus; Sin3 complex Molecular Function:histone deacetylase activity; protein binding Biological Process: cellular lipid metabolic process; histone deacetylation; negative regulation of transcription from RNA polymerase II promoter |
| UniProt Code: | O75182 |
| NCBI GenInfo Identifier: | 68067946 |
| NCBI Gene ID: | 23309 |
| NCBI Accession: | O75182.2 |
| UniProt Secondary Accession: | O75182,Q2NL91, Q68GC2, Q6P4B8, Q8TB34, Q9BSC8, |
| UniProt Related Accession: | O75182 |
| Molecular Weight: | 133kDa |
| NCBI Full Name: | Paired amphipathic helix protein Sin3b |
| NCBI Synonym Full Names: | SIN3 transcription regulator family member B |
| NCBI Official Symbol: | SIN3B |
| NCBI Protein Information: | paired amphipathic helix protein Sin3b |
| UniProt Protein Name: | Paired amphipathic helix protein Sin3b |
| UniProt Synonym Protein Names: | Histone deacetylase complex subunit Sin3b; Transcriptional corepressor Sin3b |
| Protein Family: | Paired amphipathic helix protein |
| UniProt Gene Name: | SIN3B |
 | Western blot analysis of extracts of various cell lines, using SIN3B antibody (CAB10584) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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