Anti-SIK1 Antibody (CAB15247)
- SKU:
- CAB15247
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| 抗体名: | Anti-SIK1 Antibody |
| 抗体コード: | CAB15247 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SIK1 (NP_775490.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse |
| ポジティブサンプル: |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SIK1 (NP_775490.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MVIM SEFS ADPA GQGQ GQQK PLRV GFYD IERT LGKG NFAV VKLA RHRV TKTQ VAIK IIDK TRLD SSNL EKIY REVQ LMKL LNHP HIIK LYQV METK DMLY |
| 遺伝子ID: | 150094 |
| Uniprot: | P57059 |
| セルラーロケーション: | Cytoplasm, Nucleus |
| 計算された分子量: | 84kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | SIK1, MSK, SIK, SIK-1, SNF1LK, EIEE30 |
| バックグラウンド: |
| UniProt Protein Function: | SIK: Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, TORC1/CRTC1 and TORC2/CRTC2. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators TORC1/CRTC1 and TORC2/CRTC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. Interacts with ATP1A1. Interacts (when phosphorylated on Thr-182 and Ser-186) with YWHAZ. Activated by phosphorylation on Thr-182. Also activated by phosphorylation on Thr-322 in response to increases in intracellular sodium in parallel with elevations in intracellular calcium through the reversible sodium/calcium exchanger. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily. |
| UniProt Protein Details: | Protein type:EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor; Kinase, protein; Protein kinase, CAMK; Motility/polarity/chemotaxis; CAMK group; CAMKL family; QIK subfamily Chromosomal Location of Human Ortholog: 21q22.3 Cellular Component: cytoplasm; nucleus Molecular Function:ATP binding; cAMP response element binding protein binding; magnesium ion binding; protein binding; protein kinase binding; protein serine/threonine kinase activity Biological Process: cardiac muscle cell differentiation; cellular response to hormone stimulus; entrainment of circadian clock by photoperiod; inhibition of CREB transcription factor; negative regulation of gluconeogenesis; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell differentiation; regulation of mitotic cell cycle; regulation of sodium ion transport Disease: Epileptic Encephalopathy, Early Infantile, 30 |
| UniProt Code: | P57059 |
| NCBI GenInfo Identifier: | 59803093 |
| NCBI Gene ID: | 102724428 |
| NCBI Accession: | P57059.2 |
| UniProt Secondary Accession: | P57059,Q5R2V5, Q6ZNL8, Q86YJ2, A6NC84, |
| Molecular Weight: | 84,902 Da |
| NCBI Full Name: | Serine/threonine-protein kinase SIK1 |
| NCBI Official Symbol: | LOC102724428 |
| NCBI Protein Information: | serine/threonine-protein kinase SIK1 |
| UniProt Protein Name: | Serine/threonine-protein kinase SIK1 |
| UniProt Synonym Protein Names: | Salt-inducible kinase 1; SIK-1; Serine/threonine-protein kinase SNF1-like kinase 1; Serine/threonine-protein kinase SNF1LK |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | SIK1 |
| UniProt Entry Name: | SIK1_HUMAN |