Anti-SIGLEC5 Antibody (CAB4250)
- SKU:
- CAB4250
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-SIGLEC5 Antibody |
抗体コード: | CAB4250 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 452-551 of human SIGLEC5 (NP_003821.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: | K-562 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 452-551 of human SIGLEC5 (NP_003821.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | ICLC LIFF LIVK ARRK QAAG RPEK MDDE DPIM GTIT SGSR KKPW PDSP GDQA SPPG DAPP LEEQ KELH YASL SFSE MKSR EPKD QEAP STTE YSEI KTSK |
遺伝子ID: | 8778 |
Uniprot: | O15389 |
セルラーロケーション: | Membrane, Single-pass type I membrane protein |
計算された分子量: | 60kDa |
観察された分子量: | 140kDa |
同義語: | SIGLEC5, CD170, CD33L2, OB-BP2, OBBP2, SIGLEC-5 |
バックグラウンド: | This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. |
UniProt Protein Function: | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. |
NCBI Summary: | This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012] |
UniProt Code: | O15389 |
NCBI GenInfo Identifier: | 25009254 |
NCBI Gene ID: | 8778 |
NCBI Accession: | O15389.1 |
UniProt Related Accession: | O15389 |
Molecular Weight: | 60,715 Da |
NCBI Full Name: | Sialic acid-binding Ig-like lectin 5 |
NCBI Synonym Full Names: | sialic acid binding Ig like lectin 5 |
NCBI Official Symbol: | SIGLEC5 |
NCBI Official Synonym Symbols: | CD170; OBBP2; CD33L2; OB-BP2; SIGLEC-5 |
NCBI Protein Information: | sialic acid-binding Ig-like lectin 5 |
UniProt Protein Name: | Sialic acid-binding Ig-like lectin 5 |
UniProt Synonym Protein Names: | CD33 antigen-like 2; Obesity-binding protein 2; OB-BP2; OB-binding protein 2; CD_antigen: CD170 |
UniProt Gene Name: | SIGLEC5 |
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