| UniProt Protein Function: | Involved in the generation of internal asymmetric signals required for neuronal polarization and neurite outgrowth. Mediates netrin-1-induced F-actin-substrate coupling or 'clutch engagement' within the axon growth cone through activation of CDC42, RAC1 and PAK1-dependent signaling pathway, thereby converting the F-actin retrograde flow into traction forces, concomitantly with filopodium extension and axon outgrowth. Plays a role in cytoskeletal organization by regulating the subcellular localization of phosphoinositide 3-kinase (PI3K) activity at the axonal growth cone. Plays also a role in regenerative neurite outgrowth. In the developing cortex, cooperates with KIF20B to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in the accumulation of phosphatidylinositol 3,4,5-trisphosphate (PIP3) in the growth cone of primary hippocampal neurons. |
| UniProt Code: | A0MZ66 |
| NCBI GenInfo Identifier: | 187761324 |
| NCBI Gene ID: | 57698 |
| NCBI Accession: | NP_001120683.1 |
| UniProt Secondary Accession: | A0MZ66,Q68DG1, Q6PIM5, Q9HCH4, A8MYU7, B3KRD3, B3KRH2 B3KTE0, B3KTJ7, B3KTJ8, B4E3U1, B7Z7Z9, |
| UniProt Related Accession: | A0MZ66 |
| Molecular Weight: | 23kDa, 52-73kDa |
| NCBI Full Name: | shootin-1 isoform a |
| NCBI Synonym Full Names: | shootin 1 |
| NCBI Official Symbol: | SHTN1 |
| NCBI Official Synonym Symbols: | KIAA1598; shootin-1 |
| NCBI Protein Information: | shootin-1 |
| UniProt Protein Name: | Shootin-1 |
| UniProt Synonym Protein Names: | Shootin1 |
| Protein Family: | Shootin |
| UniProt Gene Name: | SHTN1 |
