Anti-SHFM1 Antibody (CAB18152)
- SKU:
- CAB18152
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
抗体名: | Anti-SHFM1 Antibody |
抗体コード: | CAB18152 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant protein of human SHFM1. |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human |
ポジティブサンプル: |
免疫原: | Recombinant protein of human SHFM1. |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 7979 |
Uniprot: | P60896 |
セルラーロケーション: | |
計算された分子量: | |
観察された分子量: | Refer to figures |
同義語: | C7orf76, DSS1, ECD, SHFD1, SHFM1, SHSF1, Shfdg1, SEM1 |
バックグラウンド: |
UniProt Protein Function: | Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:15117943). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription-associated genomic instability. R-loop accumulation increases in SEM1-depleted cells. |
NCBI Summary: | The product of this gene has been localized within the split hand/split foot malformation locus SHFM1 at chromosome 7. It has been proposed to be a candidate gene for the autosomal dominant form of the heterogeneous limb developmental disorder split hand/split foot malformation type 1. In addition, it has been shown to directly interact with BRCA2. It also may play a role in the completion of the cell cycle. [provided by RefSeq, Jul 2008] |
UniProt Code: | P60896 |
NCBI GenInfo Identifier: | 5453640 |
NCBI Gene ID: | 7979 |
NCBI Accession: | NP_006295.1 |
UniProt Secondary Accession: | P60896,Q13437, Q61067, |
UniProt Related Accession: | P60896,Q6ZVN7 |
Molecular Weight: | 8-10 kDa |
NCBI Full Name: | 26S proteasome complex subunit SEM1 isoform 3 |
NCBI Synonym Full Names: | SEM1, 26S proteasome complex subunit |
NCBI Official Symbol: | SEM1 |
NCBI Official Synonym Symbols: | ECD; DSS1; SHFD1; SHFM1; SHSF1; Shfdg1; C7orf76 |
NCBI Protein Information: | 26S proteasome complex subunit SEM1 |
UniProt Protein Name: | 26S proteasome complex subunit SEM1 |
UniProt Synonym Protein Names: | 26S proteasome complex subunit DSS1; Deleted in split hand/split foot protein 1; Split hand/foot deleted protein 1; Split hand/foot malformation type 1 protein |
Protein Family: | Exoribonuclease |
UniProt Gene Name: | SEM1 |