Anti-SHANK2 Antibody (CAB18423)
- SKU:
- CAB18423
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
抗体名: | Anti-SHANK2 Antibody |
抗体コード: | CAB18423 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant protein of human SHANK2. |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | Mouse liver, Rat liver |
免疫原: | Recombinant protein of human SHANK2. |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 22941 |
Uniprot: | Q9UPX8 |
セルラーロケーション: | |
計算された分子量: | |
観察された分子量: | 159kDa |
同義語: | AUTS17, CORTBP1, CTTNBP1, ProSAP1, SHANK, SPANK-3, SHANK2 |
バックグラウンド: |
UniProt Protein Function: | Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction. |
NCBI Summary: | This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] |
UniProt Code: | Q9UPX8 |
NCBI GenInfo Identifier: | 254763402 |
NCBI Gene ID: | 22941 |
NCBI Accession: | Q9UPX8.3 |
UniProt Secondary Accession: | Q9UPX8,Q3Y8G9, Q52LK2, Q9UKP1, C0SPG8, C0SPG9, |
UniProt Related Accession: | Q9UPX8 |
Molecular Weight: | 134,931 Da |
NCBI Full Name: | SH3 and multiple ankyrin repeat domains protein 2 |
NCBI Synonym Full Names: | SH3 and multiple ankyrin repeat domains 2 |
NCBI Official Symbol: | SHANK2 |
NCBI Official Synonym Symbols: | SHANK; AUTS17; CORTBP1; CTTNBP1; ProSAP1; SPANK-3 |
NCBI Protein Information: | SH3 and multiple ankyrin repeat domains protein 2 |
UniProt Protein Name: | SH3 and multiple ankyrin repeat domains protein 2 |
UniProt Synonym Protein Names: | Cortactin-binding protein 1; CortBP1; Proline-rich synapse-associated protein 1 |
Protein Family: | SH3 and multiple ankyrin repeat domains protein |
UniProt Gene Name: | SHANK2 |
UniProt Entry Name: | SHAN2_HUMAN |