Anti-SGCG Antibody (CAB10540)
- SKU:
- CAB10540
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-SGCG Antibody |
| 抗体コード: | CAB10540 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 72-291 of human SGCG (NP_000222.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | HeLa, MCF7 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 72-291 of human SGCG (NP_000222.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | CVTK DGLR LEGE SEFL FPLY AKEI HSRV DSSL LLQS TQNV TVNA RNSE GEVT GRLK VGPK MVEV QNQQ FQIN SNDG KPLF TVDE KEVV VGTD KLRV TGPE GALF EHSV ETPL VRAD PFQD LRLE SPTR SLSM DAPR GVHI QAHA GKIE ALSQ MDIL FHSS DGML VLDA ETVC LPKL VQGT WGPS GSSQ SLYE ICVC PDGK LYLS VAGV STTC QEHS HICL |
| 遺伝子ID: | 6445 |
| Uniprot: | Q13326 |
| セルラーロケーション: | Cell membrane, Cytoplasm, Single-pass type II membrane protein, cytoskeleton, sarcolemma |
| 計算された分子量: | 32kDa |
| 観察された分子量: | 37kDa |
| 同義語: | SGCG, 35DAG, A4, DAGA4, DMDA, DMDA1, LGMD2C, MAM, SCARMD2, SCG3, gamma-SG |
| バックグラウンド: | This gene encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C). |
| UniProt Protein Function: | SGCG: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Defects in SGCG are the cause of limb-girdle muscular dystrophy type 2C (LGMD2C). LGMD2C is characterized by progressive muscle wasting from early childhood. Belongs to the sarcoglycan beta/delta/gamma/zeta family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Dystrophin complex Chromosomal Location of Human Ortholog: 13q12 Cellular Component: cytoskeleton; cytoplasm; plasma membrane; integral to membrane; sarcoglycan complex; sarcolemma Molecular Function:protein binding Biological Process: cardiac muscle development; muscle development; heart contraction; muscle cell development Disease: Muscular Dystrophy, Limb-girdle, Type 2c |
| NCBI Summary: | This gene encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C). [provided by RefSeq, Oct 2008] |
| UniProt Code: | Q13326 |
| NCBI GenInfo Identifier: | 313104319 |
| NCBI Gene ID: | 6445 |
| NCBI Accession: | Q13326.4 |
| UniProt Secondary Accession: | Q13326,Q32M32, Q5T9J6, |
| UniProt Related Accession: | Q13326 |
| Molecular Weight: | 291 |
| NCBI Full Name: | Gamma-sarcoglycan |
| NCBI Synonym Full Names: | sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) |
| NCBI Official Symbol: | SGCG |
| NCBI Official Synonym Symbols: | A4; MAM; DMDA; SCG3; TYPE; DAGA4; DMDA1; LGMD2C; SCARMD2 |
| NCBI Protein Information: | gamma-sarcoglycan; 35DAG; gamma-SG; gamma sarcoglycan; 35kD dystrophin-associated glycoprotein; 35 kDa dystrophin-associated glycoprotein |
| UniProt Protein Name: | Gamma-sarcoglycan |
| UniProt Synonym Protein Names: | 35 kDa dystrophin-associated glycoprotein; 35DAG |
| Protein Family: | Gamma-sarcoglycan |
| UniProt Gene Name: | SGCG |
| UniProt Entry Name: | SGCG_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SGCG antibody (CAB10540) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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