Anti-SGCD Antibody (CAB6980)
- SKU:
- CAB6980
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-SGCD Antibody |
| 抗体コード: | CAB6980 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 61-290 of human SGCD (NP_000328.2). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Jurkat, THP-1, Mouse heart, Mouse skeletal muscle, Rat heart, Rat skeletal muscle |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 61-290 of human SGCD (NP_000328.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | NFTI DGMG NLRI TEKG LKLE GDSE FLQP LYAK EIQS RPGN ALYF KSAR NVTV NILN DQTK VLTQ LITG PKAV EAYG KKFE VKTV SGKL LFSA DNNE VVVG AERL RVLG AEGT VFPK SIET PNVR ADPF KELR LESP TRSL VMEA PKGV EINA EAGN MEAT CRTE LRLE SKDG EIKL DAAK IRLP RLPH GSYT PTGT RQKV FEIC VCAN GRLF LSQA GAGS TCQI NTSV CL |
| 遺伝子ID: | 6444 |
| Uniprot: | Q92629 |
| セルラーロケーション: | Cell membrane, Cytoplasm, Single-pass type II membrane protein, cytoskeleton, sarcolemma |
| 計算された分子量: | 28kDa/32kDa |
| 観察された分子量: | 37kDa |
| 同義語: | SGCD, 35DAG, CMD1L, DAGD, SG-delta, SGCDP, SGD |
| バックグラウンド: | The protein encoded by this gene is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC). DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. This protein is expressed most abundantly in skeletal and cardiac muscle. Mutations in this gene have been associated with autosomal recessive limb-girdle muscular dystrophy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. |
| UniProt Protein Function: | SGCD: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. Defects in SGCD are the cause of limb-girdle muscular dystrophy type 2F (LGMD2F). LGMD2F is an autosomal recessive disorder. Defects in SGCD are the cause of cardiomyopathy dilated type 1L (CMD1L). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Belongs to the sarcoglycan beta/delta/gamma/zeta family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Dystrophin complex; Membrane protein, integral Chromosomal Location of Human Ortholog: 5q33-q34 Cellular Component: dystrophin-associated glycoprotein complex; cytoskeleton; cytoplasm; integral to membrane; plasma membrane; sarcoglycan complex; sarcolemma Biological Process: cardiac muscle development; muscle development; heart contraction; muscle cell development Disease: Muscular Dystrophy, Limb-girdle, Type 2f; Cardiomyopathy, Dilated, 1l |
| NCBI Summary: | The protein encoded by this gene is one of the four known components of the sarcoglycan complex, which is a subcomplex of the dystrophin-glycoprotein complex (DGC). DGC forms a link between the F-actin cytoskeleton and the extracellular matrix. This protein is expressed most abundantly in skeletal and cardiac muscle. Mutations in this gene have been associated with autosomal recessive limb-girdle muscular dystrophy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q92629 |
| NCBI GenInfo Identifier: | 212276471 |
| NCBI Gene ID: | 6444 |
| NCBI Accession: | Q92629.2 |
| UniProt Secondary Accession: | Q92629,Q53XA5, Q99644, A8K9S9, |
| UniProt Related Accession: | Q92629 |
| Molecular Weight: | 289 |
| NCBI Full Name: | Delta-sarcoglycan |
| NCBI Synonym Full Names: | sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) |
| NCBI Official Symbol: | SGCD |
| NCBI Official Synonym Symbols: | SGD; DAGD; 35DAG; CMD1L; SGCDP; SG-delta |
| NCBI Protein Information: | delta-sarcoglycan; delta-SG; placental delta sarcoglycan; 35 kDa dystrophin-associated glycoprotein; dystrophin associated glycoprotein, delta sarcoglycan |
| UniProt Protein Name: | Delta-sarcoglycan |
| UniProt Synonym Protein Names: | 35 kDa dystrophin-associated glycoprotein; 35DAG |
| Protein Family: | Delta-sarcoglycan |
| UniProt Gene Name: | SGCD |
| UniProt Entry Name: | SGCD_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SGCD antibody (CAB6980) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat heart using SGCD antibody (CAB6980) at dilution of 1:100 (40x lens). |
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