Anti-SFTPA1 Antibody (CAB3133)
- SKU:
- CAB3133
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-SFTPA1 Antibody |
| 抗体コード: | CAB3133 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide of human SFTPA1 |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:1000 IHC 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse lung, Rat lung |
| 免疫原: | A synthetic peptide of human SFTPA1 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 653509 |
| Uniprot: | Q8IWL2 |
| セルラーロケーション: | Secreted, extracellular matrix, extracellular space, surface film |
| 計算された分子量: | 26kDa/27kDa |
| 観察された分子量: | 30KDa |
| 同義語: | SFTPA1, COLEC4, PSAP, PSP-A, PSPA, SFTP1, SFTPA1B, SP-A, SP-A1, SPA, SPA1 |
| バックグラウンド: | This gene encodes a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. The encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. Mutations in this gene are associated with idiopathic pulmonary fibrosis. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | SFTPA1B: In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Genetic variations in SFTPA1 are a cause of susceptibility to pulmonary fibrosis idiopathic (IPF). Pulmonary fibrosis is a lung disease characterized by shortness of breath, radiographically evident diffuse pulmonary infiltrates, and varying degrees of inflammation and fibrosis on biopsy. It results in acute lung injury with subsequent scarring and endstage lung disease. Genetic variations in SFTPA1 are a cause of susceptibility to respiratory distress syndrome in premature infants (RDS); also known as RDS in prematurity. RDS is a lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'. The association between SFTPA1 alleles and respiratory distress syndrome in premature infants is dependent on a variation Ile to Thr at position 131 in SFTPB. Belongs to the SFTPA family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 10q22.3 Cellular Component: extracellular space; proteinaceous extracellular matrix; collagen; extracellular region Molecular Function:lipid transporter activity; carbohydrate binding Biological Process: respiratory gaseous exchange; lipid transport Disease: Pulmonary Fibrosis, Idiopathic |
| NCBI Summary: | This gene encodes a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. The encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. Mutations in this gene are associated with idiopathic pulmonary fibrosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010] |
| UniProt Code: | Q8IWL2 |
| NCBI GenInfo Identifier: | 60416440 |
| NCBI Gene ID: | 653509 |
| NCBI Accession: | Q8IWL2.2 |
| UniProt Secondary Accession: | Q8IWL2,P07714, Q14DV4, Q5RIR5, Q5RIR7, A8K3T8, B7ZW50 E3VLD8, E3VLD9, E3VLE0, E3VLE1, G5E9J3, |
| UniProt Related Accession: | Q8IWL2 |
| Molecular Weight: | 27,736 Da |
| NCBI Full Name: | Pulmonary surfactant-associated protein A1 |
| NCBI Synonym Full Names: | surfactant protein A1 |
| NCBI Official Symbol: | SFTPA1 |
| NCBI Official Synonym Symbols: | SPA; PSAP; PSPA; SP-A; SPA1; PSP-A; SFTP1; SP-A1; COLEC4; SFTPA1B |
| NCBI Protein Information: | pulmonary surfactant-associated protein A1; collectin-4; surfactant protein A1B; alveolar proteinosis protein; surfactant protein A1 variant AD' 6A; surfactant protein A1 variant ACD' 6A; surfactant protein A1 variant AD' 6A2; surfactant protein A1 variant AD' 6A3; surfactant protein A1 variant AD' 6A4; surfactant protein A1 variant AB'D' 6A; surfactant protein A1 variant ACD' 6A2; surfactant protein A1 variant ACD' 6A3; surfactant protein A1 variant ACD' 6A4; surfactant protein A1 variant AB'D' 6A2; surfactant protein A1 variant AB'D' 6A3; surfactant protein A1 variant AB'D' 6A4; surfactant, pulmonary-associated protein A1A; surfactant, pulmonary-associated protein A1B; 35 kDa pulmonary surfactant-associated protein |
| UniProt Protein Name: | Pulmonary surfactant-associated protein A1 |
| UniProt Synonym Protein Names: | 35 kDa pulmonary surfactant-associated protein; Alveolar proteinosis protein; Collectin-4 |
| Protein Family: | Pulmonary surfactant-associated protein |
| UniProt Gene Name: | SFTPA1 |
| UniProt Entry Name: | SFTA1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SFTPA1 antibody (CAB3133) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunohistochemistry of paraffin-embedded rat lung using SFTPA1 Rabbit pAb (CAB3133) at dilution of 1:50 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human lung cancer using SFTPA1 Rabbit pAb (CAB3133) at dilution of 1:50 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse lung using SFTPA1 Rabbit pAb (CAB3133) at dilution of 1:50 (40x lens). |
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