Anti-SFRP4 Antibody (CAB4189)
- SKU:
- CAB4189
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Developmental Biology
Frequently bought together:
Description
| 抗体名: | Anti-SFRP4 Antibody |
| 抗体コード: | CAB4189 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthesized peptide derived from human SFRP4 |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa, MCF7, SKOV3, Rat ovary |
| 免疫原: | A synthesized peptide derived from human SFRP4 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 6424 |
| Uniprot: | Q6FHJ7 |
| セルラーロケーション: | |
| 計算された分子量: | 50kDa |
| 観察された分子量: | 50KDa |
| 同義語: | FRP-4, FRPHE, PYL, sFRP-4 |
| バックグラウンド: | Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | SFRP4: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 may act as a regulator of adult uterine morphology and function. Increases apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling. Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake. Belongs to the secreted frizzled-related protein (sFRP) family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 7p14.1 Cellular Component: cell surface; cytoplasm; extracellular space; integral to membrane; nucleus Molecular Function:G-protein coupled receptor activity; protein binding; Wnt receptor activity; Wnt-protein binding Biological Process: negative regulation of cell proliferation; negative regulation of transcription factor activity; phosphate ion homeostasis; positive regulation of apoptosis; positive regulation of epidermal cell differentiation; positive regulation of receptor internalization |
| NCBI Summary: | Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q6FHJ7 |
| NCBI GenInfo Identifier: | 61216780 |
| NCBI Gene ID: | 6424 |
| NCBI Accession: | Q6FHJ7.2 |
| UniProt Secondary Accession: | Q6FHJ7,O14877, Q05BG7, Q1ZYW2, Q4G124, Q6FHM0, Q6PD64 B4DYC1, |
| UniProt Related Accession: | Q6FHJ7 |
| Molecular Weight: | 39,827 Da |
| NCBI Full Name: | Secreted frizzled-related protein 4 |
| NCBI Synonym Full Names: | secreted frizzled related protein 4 |
| NCBI Official Symbol: | SFRP4 |
| NCBI Official Synonym Symbols: | PYL; FRP-4; FRPHE; sFRP-4 |
| NCBI Protein Information: | secreted frizzled-related protein 4 |
| UniProt Protein Name: | Secreted frizzled-related protein 4 |
| UniProt Synonym Protein Names: | Frizzled protein, human endometrium; FrpHE |
| Protein Family: | Secreted frizzled-related protein |
| UniProt Gene Name: | SFRP4 |
| UniProt Entry Name: | SFRP4_HUMAN |
 | Western blot - SFRP4 Rabbit mAb (CAB4189) |
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