Anti-SF3B4 Antibody (CAB17608)
- SKU:
- CAB17608
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-SF3B4 Antibody |
| 抗体コード: | CAB17608 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human SF3B4 (NP_005841.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Rat spleen, Rat lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human SF3B4 (NP_005841.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAAG PISE RNQD ATVY VGGL DEKV SEPL LWEL FLQA GPVV NTHM PKDR VTGQ HQGY GFVE FLSE EDAD YAIK IMNM IKLY GKPI RVNK ASAH NKNL DVGA NIFI GNLD PEID EKLL YDTF SAFG VILQ TPKI MRDP DTGN SKGY AFIN FASF DASD AAIE AMNG QYLC NRPI TVSY AFKK DSKG ERHG SAAE RLLA AQNP |
| 遺伝子ID: | 10262 |
| Uniprot: | Q15427 |
| セルラーロケーション: | |
| 計算された分子量: | 44kDa |
| 観察された分子量: | 44kDa |
 | Western blot - SF3B4 Polyclonal Antibody (CAB17608) |
| 同義語: | AFD1, Hsh49, SAP49, SF3b49, SF3B4 |
| バックグラウンド: | This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly to pre-mRNA. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | SF3B4: subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. |
| UniProt Protein Details: | Protein type:RNA-binding; Spliceosome; RNA splicing Chromosomal Location of Human Ortholog: 1q21.2 Cellular Component: nucleoplasm; spliceosome; U12-dependent spliceosome Molecular Function:protein binding Biological Process: mRNA processing; nuclear mRNA splicing, via spliceosome; RNA splicing; RNA splicing, via transesterification reactions Disease: Acrofacial Dysostosis 1, Nager Type |
| NCBI Summary: | This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in the pre-mRNA immediately upstream of the branchpoint sequence in pre-mRNA in the prespliceosomal complex A. It also may be involved in the assembly of the B, C and E spliceosomal complexes. In addition to RNA-binding activity, this protein interacts directly and highly specifically with subunit 2 of the splicing factor 3B. This protein contains two N-terminal RNA-recognition motifs (RRMs), consistent with the observation that it binds directly to pre-mRNA. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q15427 |
| NCBI GenInfo Identifier: | 2500587 |
| NCBI Gene ID: | 10262 |
| NCBI Accession: | Q15427.1 |
| UniProt Secondary Accession: | Q15427,Q5SZ63, |
| UniProt Related Accession: | Q15427 |
| Molecular Weight: | 44,386 Da |
| NCBI Full Name: | Splicing factor 3B subunit 4 |
| NCBI Synonym Full Names: | splicing factor 3b subunit 4 |
| NCBI Official Symbol: | SF3B4 |
| NCBI Official Synonym Symbols: | AFD1; Hsh49; SAP49; SF3b49 |
| NCBI Protein Information: | splicing factor 3B subunit 4 |
| UniProt Protein Name: | Splicing factor 3B subunit 4 |
| UniProt Synonym Protein Names: | Pre-mRNA-splicing factor SF3b 49 kDa subunit; SF3b50; Spliceosome-associated protein 49; SAP 49 |
| Protein Family: | Splicing factor |
| UniProt Gene Name: | SF3B4 |
| UniProt Entry Name: | SF3B4_HUMAN |