Anti-SF3B2 Antibody (CAB5875)
- SKU:
- CAB5875
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
抗体名: | Anti-SF3B2 Antibody |
抗体コード: | CAB5875 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 616-895 of human SF3B2 (NP_006833.2). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HeLa, MCF7, SW620, A375, Mouse testis |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 616-895 of human SF3B2 (NP_006833.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | SLGM PVGP NAHK VPPP WLIA MQRY GPPP SYPN LKIP GLNS PIPE SCSF GYHA GGWG KPPV DETG KPLY GDVF GTNA AEFQ TKTE EEEI DRTP WGEL EPSD EESS EEEE EEES DEDK PDET GFIT PADS GLIT PGGF SSVP AGME TPEL IELR KKKI EEAM DGSE TPQL FTVL PEKR TATV GGAM MGST HIYD MSTV MSRK GPAP ELQG VEVA LAPE ELEL DPMA MTQK YEEH VREQ QAQV EKED FSDM VAEH AAKQ KQKK RKAQ PQDS RGGS KKYK EFKF |
遺伝子ID: | 10992 |
Uniprot: | Q13435 |
セルラーロケーション: | Nucleus |
計算された分子量: | 100kDa |
観察された分子量: | 140kDa |
同義語: | SF3B2, Cus1, SAP145, SF3B145, SF3b1, SF3b150 |
バックグラウンド: | This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus. |
UniProt Protein Function: | SF3B2: subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (bps) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. |
UniProt Protein Details: | Protein type:RNA-binding; RNA splicing; Spliceosome; RNA processing Chromosomal Location of Human Ortholog: 11q13.1 Cellular Component: nucleoplasm; snRNP U2; spliceosome; U12-dependent spliceosome Molecular Function:protein binding Biological Process: mRNA processing; nuclear mRNA splicing, via spliceosome; RNA splicing |
NCBI Summary: | This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q13435 |
NCBI GenInfo Identifier: | 296452908 |
NCBI Gene ID: | 10992 |
NCBI Accession: | Q13435.2 |
UniProt Secondary Accession: | Q13435,Q7L4T5, Q7Z627, Q969K1, Q96CM6, Q9BWD2, A8K485 B4DT19, |
UniProt Related Accession: | Q13435 |
Molecular Weight: | 100,228 Da |
NCBI Full Name: | Splicing factor 3B subunit 2 |
NCBI Synonym Full Names: | splicing factor 3b subunit 2 |
NCBI Official Symbol: | SF3B2 |
NCBI Official Synonym Symbols: | Cus1; SF3b1; SAP145; SF3B145; SF3b150 |
NCBI Protein Information: | splicing factor 3B subunit 2 |
UniProt Protein Name: | Splicing factor 3B subunit 2 |
UniProt Synonym Protein Names: | Pre-mRNA-splicing factor SF3b 145 kDa subunit; SF3b145; SF3b150; Spliceosome-associated protein 145; SAP 145 |
Protein Family: | Splicing factor |
UniProt Gene Name: | SF3B2 |
UniProt Entry Name: | SF3B2_HUMAN |
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