Anti-SERPINI1 Antibody (CAB15703)
- SKU:
- CAB15703
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-SERPINI1 Antibody |
抗体コード: | CAB15703 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 181-410 of human SERPINI1 (NP_005016.1). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
反応性: | Mouse, Rat |
ポジティブサンプル: | Mouse brain, Rat brain |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 181-410 of human SERPINI1 (NP_005016.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | INAV YFKG NWKS QFRP ENTR TFSF TKDD ESEV QIPM MYQQ GEFY YGEF SDGS NEAG GIYQ VLEI PYEG DEIS MMLV LSRQ EVPL ATLE PLVK AQLV EEWA NSVK KQKV EVYL PRFT VEQE IDLK DVLK ALGI TEIF IKDA NLTG LSDN KEIF LSKA IHKS FLEV NEEG SEAA AVSG MIAI SRMA VLYP QVIV DHPF FFLI RNRR TGTI LFMG RVMH PETM NTSG HDFE EL |
遺伝子ID: | 5274 |
Uniprot: | Q99574 |
セルラーロケーション: | Secreted |
計算された分子量: | 46kDa |
観察された分子量: | 46kDa |
同義語: | SERPINI1, PI12 |
バックグラウンド: | This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified. |
UniProt Protein Function: | SERPINI1: Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator. Defects in SERPINI1 are the cause of familial encephalopathy with neuroserpin inclusion bodies (FEN1B). FEN1B is characterized clinically as an autosomal dominantly inherited dementia, histologically by unique neuronal inclusion bodies and biochemically by polymers of neuroserpin. Belongs to the serpin family. |
UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 3q26.1 Cellular Component: extracellular space Molecular Function:serine-type endopeptidase inhibitor activity Biological Process: regulation of cell adhesion; central nervous system development; peripheral nervous system development Disease: Encephalopathy, Familial, With Neuroserpin Inclusion Bodies |
NCBI Summary: | This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q99574 |
NCBI GenInfo Identifier: | 3183087 |
NCBI Gene ID: | 5274 |
NCBI Accession: | Q99574.1 |
UniProt Secondary Accession: | Q99574,Q6AHZ4, A8K217, D3DNP1, |
UniProt Related Accession: | Q99574 |
Molecular Weight: | 46,427 Da |
NCBI Full Name: | Neuroserpin |
NCBI Synonym Full Names: | serpin peptidase inhibitor, clade I (neuroserpin), member 1 |
NCBI Official Symbol: | SERPINI1 |
NCBI Official Synonym Symbols: | PI12; neuroserpin |
NCBI Protein Information: | neuroserpin; PI-12; serpin I1; peptidase inhibitor 12; serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1 |
UniProt Protein Name: | Neuroserpin |
UniProt Synonym Protein Names: | Peptidase inhibitor 12; PI-12; Serpin I1 |
Protein Family: | Neuroserpin |
UniProt Gene Name: | SERPINI1 |
UniProt Entry Name: | NEUS_HUMAN |
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