Anti-SERPINC1 Antibody (CAB1574)
- SKU:
- CAB1574
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Frequently bought together:
Description
| 抗体名: | Anti-SERPINC1 Antibody |
| 抗体コード: | CAB1574 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 33-185 of human SERPINC1 (NP_000479.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | U-251MG, HepG2, PC-3, HO-8910, Mouse liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 33-185 of human SERPINC1 (NP_000479.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | HGSP VDIC TAKP RDIP MNPM CIYR SPEK KATE DEGS EQKI PEAT NRRV WELS KANS RFAT TFYQ HLAD SKND NDNI FLSP LSIS TAFA MTKL GACN DTLQ QLME VFKF DTIS EKTS DQIH FFFA KLNC RLYR KANK SSKL VSAN RLFG DKSL T |
| 遺伝子ID: | 462 |
| Uniprot: | P01008 |
| セルラーロケーション: | Secreted, extracellular space |
| 計算された分子量: | 52kDa |
| 観察された分子量: | 60kDa |
| 同義語: | SERPINC1, AT3, AT3D, ATIII, THPH7 |
| バックグラウンド: | The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. |
| UniProt Protein Function: | SERPINC1: Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. Defects in SERPINC1 are the cause of antithrombin III deficiency (AT3D). AT3D is an important risk factor for hereditary thrombophilia, a hemostatic disorder characterized by a tendency to recurrent thrombosis. AT3D is classified into 4 types. Type I: characterized by a 50% decrease in antigenic and functional levels. Type II: has defects affecting the thrombin- binding domain. Type III: alteration of the heparin-binding domain. Plasma AT-III antigen levels are normal in type II and III. Type IV: consists of miscellaneous group of unclassifiable mutations. Belongs to the serpin family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Inhibitor Chromosomal Location of Human Ortholog: 1q25.1 Cellular Component: extracellular space; plasma membrane; extracellular region Molecular Function:heparin binding; serine-type endopeptidase inhibitor activity; protein binding; protease binding Biological Process: negative regulation of inflammatory response; blood coagulation; response to nutrient Disease: Antithrombin Iii Deficiency |
| NCBI Summary: | The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009] |
| UniProt Code: | P01008 |
| NCBI GenInfo Identifier: | 113936 |
| NCBI Gene ID: | 462 |
| NCBI Accession: | P01008.1 |
| UniProt Secondary Accession: | P01008,P78439, P78447, Q13815, Q5TC78, Q7KZ43, Q7KZ97 Q9UC78, B2R6P0, |
| UniProt Related Accession: | P01008 |
| Molecular Weight: | 464 |
| NCBI Full Name: | Antithrombin-III |
| NCBI Synonym Full Names: | serpin peptidase inhibitor, clade C (antithrombin), member 1 |
| NCBI Official Symbol: | SERPINC1 |
| NCBI Official Synonym Symbols: | AT3; AT3D; ATIII; THPH7 |
| NCBI Protein Information: | antithrombin-III; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1 |
| UniProt Protein Name: | Antithrombin-III |
| UniProt Synonym Protein Names: | Serpin C1 |
| UniProt Gene Name: | SERPINC1 |
| UniProt Entry Name: | ANT3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SERPINC1 antibody (CAB1574) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunofluorescence analysis of U2OS cells using SERPINC1 antibody (CAB1574). Blue: DAPI for nuclear staining. |
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