Anti-SERPINB8 Antibody (CAB13039)
- SKU:
- CAB13039
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-SERPINB8 Antibody |
| 抗体コード: | CAB13039 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 173-242 of human SERPINB8 (NP_001027018.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Jurkat, Mouse lung, Rat lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 173-242 of human SERPINB8 (NP_001027018.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | EQFD RKYT RGML FKTN EEKK TVQM MFKE AKFK MGYA DEVH TQVL ELPY VEEE LSMV ILLP DDNT DLAV KE |
| 遺伝子ID: | 5271 |
| Uniprot: | P50452 |
| セルラーロケーション: | Cytoplasm |
| 計算された分子量: | 22kDa/27kDa/42kDa |
| 観察された分子量: | 43kDa |
| 同義語: | SERPINB8, CAP2, PI-8, PI8, PSS5, serpin B8 |
| バックグラウンド: | The protein encoded by this gene is a member of the ov-serpin family of serine protease inhibitors. The encoded protein is produced by platelets and can bind to and inhibit the function of furin, a serine protease involved in platelet functions. In addition, this protein has been found to enhance the mechanical stability of cell-cell adhesion in the skin, and defects in this gene have been associated with an autosomal-recessive form of exfoliative ichthyosis. |
| UniProt Protein Function: | SERPINB8: Belongs to the serpin family. Ov-serpin subfamily. 2 isoforms of the human protein are produced by alternative splicing |
| UniProt Protein Details: | Protein type:Inhibitor Chromosomal Location of Human Ortholog: 18q22.1 Cellular Component: extracellular space; cytosol Molecular Function:serine-type endopeptidase inhibitor activity; protein binding |
| NCBI Summary: | The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by well-conserved a tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 [PubMed 2690952]). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-8 (PI8; SERPINB8) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 [PubMed 9268635]).[supplied by OMIM, Jan 2010] |
| UniProt Code: | P50452 |
| NCBI GenInfo Identifier: | 73623033 |
| NCBI Gene ID: | 5271 |
| NCBI Accession: | NP_001027018.1 |
| UniProt Secondary Accession: | P50452,Q7Z2V6, Q8N178, B4DTW2, |
| UniProt Related Accession: | P50452 |
| Molecular Weight: | 22,134 Da |
| NCBI Full Name: | serpin B8 isoform b |
| NCBI Synonym Full Names: | serpin peptidase inhibitor, clade B (ovalbumin), member 8 |
| NCBI Official Symbol: | SERPINB8 |
| NCBI Official Synonym Symbols: | PI8; CAP2 |
| NCBI Protein Information: | serpin B8 |
| UniProt Protein Name: | Serpin B8 |
| UniProt Synonym Protein Names: | Cytoplasmic antiproteinase 2; CAP-2; CAP2; Peptidase inhibitor 8; PI-8 |
| UniProt Gene Name: | SERPINB8 |
| UniProt Entry Name: | SPB8_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SERPINB8 antibody (CAB13039) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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