Anti-SEPT12 Antibody (CAB15564)
- SKU:
- CAB15564
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
| 抗体名: | Anti-SEPT12 Antibody |
| 抗体コード: | CAB15564 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 189-358 of human SEPT12 (NP_653206.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:200 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse brain, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 189-358 of human SEPT12 (NP_653206.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VVPV IARA DSLT MEER EAFR RRIQ QNLR THCI DVYP QMCF DEDI NDKI LNSK LRDR IPFA VVGA DQEH LVNG RCVL GRKT KWGI IEVE NMAH CEFP LLRD LLIR SHLQ DLKD ITHN IHYE NYRV IRLN ESHL LPRG PGWV NLAP ASPG QLTT PRTF KVCR GAHD DSDD EF |
| 遺伝子ID: | 124404 |
| Uniprot: | Q8IYM1 |
| セルラーロケーション: | Cell projection, Cytoplasm, cilium, cytoskeleton, flagellum, spindle |
| 計算された分子量: | 35kDa/40kDa |
| 観察された分子量: | 41kDa |
| 同義語: | SEPT12, SPGF10, septin-12 |
| バックグラウンド: | This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Septins play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | SEPT12: Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). Defects in SEPT12 are the cause of spermatogenic failure 10 (SPGF10). An infertility disorder caused by spermatogenesis defects. It results in decreased sperm motility, concentration, and multiple sperm structural defects. The most prominent feature is a defective sperm annulus, a ring structure that demarcates the midpiece and the principal piece of the sperm tail. Belongs to the septin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell cycle regulation; Cytoskeletal; Hydrolase Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: cleavage furrow; microtubule cytoskeleton; midbody; perinuclear region of cytoplasm; spindle; stress fiber Molecular Function:GDP binding; GTP binding; phosphoinositide binding; protein binding; protein homodimerization activity Disease: Spermatogenic Failure 10 |
| NCBI Summary: | This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Septins play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011] |
| UniProt Code: | Q8IYM1 |
| NCBI GenInfo Identifier: | 74750767 |
| NCBI Gene ID: | 124404 |
| NCBI Accession: | Q8IYM1.1 |
| UniProt Secondary Accession: | Q8IYM1,Q0P6B0, Q1PBH0, Q96LL0, |
| UniProt Related Accession: | Q8IYM1 |
| Molecular Weight: | 35,191 Da |
| NCBI Full Name: | Septin-12 |
| NCBI Synonym Full Names: | septin 12 |
| NCBI Official Symbol: | SEPT12 |
| NCBI Official Synonym Symbols: | SPGF10 |
| NCBI Protein Information: | septin-12 |
| UniProt Protein Name: | Septin-12 |
| UniProt Gene Name: | SEPT12 |
| UniProt Entry Name: | SEP12_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SEPT12 antibody (CAB15564) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
View AllClose