Anti-SEMA4A Antibody (CAB17205)
- SKU:
- CAB17205
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-SEMA4A Antibody |
| 抗体コード: | CAB17205 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 320-580 of human SEMA4A (NP_071762.2). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HT-29 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 320-580 of human SEMA4A (NP_071762.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | IYAV FTSQ WQVG GTRS SAVC AFSL LDIE RVFK GKYK ELNK ETSR WTTY RGPE TNPR PGSC SVGP SSDK ALTF MKDH FLMD EQVV GTPL LVKS GVEY TRLA VETA QGLD GHSH LVMY LGTT TGSL HKAV VSGD SSAH LVEE IQLF PDPE PVRN LQLA PTQG AVFV GFSG GVWR VPRA NCSV YESC VDCV LARD PHCA WDPE SRTC CLLS APNL NSWK QDME RGNP EWAC ASGP MSRS LRPQ SRPQ IIKE VLAV PNSI LELP C |
| 遺伝子ID: | 64218 |
| Uniprot: | Q9H3S1 |
| セルラーロケーション: | |
| 計算された分子量: | 69kDa/83kDa |
| 観察された分子量: | 83kDa |
 | Western blot - SEMA4A Rabbit pAb (CAB17205) |
| 同義語: | SEMA4A, CORD10, RP35, SEMAB, SEMB |
| バックグラウンド: | This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. |
| UniProt Protein Function: | SEMA4A: a single-pass type I membrane protein that inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. Defects in SEMA4A are the cause of retinitis pigmentosa type 35 and cone-rod dystrophy type 10. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 1q22 Cellular Component: extracellular space; plasma membrane Molecular Function:chemorepellent activity; protein binding; semaphorin receptor binding Biological Process: negative chemotaxis; negative regulation of axon extension involved in axon guidance; neural crest cell migration; positive regulation of cell migration Disease: Cone-rod Dystrophy 10; Retinitis Pigmentosa 35 |
| NCBI Summary: | This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010] |
| UniProt Code: | Q9H3S1 |
| NCBI GenInfo Identifier: | 29840871 |
| NCBI Gene ID: | 64218 |
| NCBI Accession: | Q9H3S1.2 |
| UniProt Secondary Accession: | Q9H3S1,Q5TCI5, Q5TCJ6, Q8WUA9, B2RDH8, B3KR76, |
| UniProt Related Accession: | Q9H3S1 |
| Molecular Weight: | 69,104 Da |
| NCBI Full Name: | Semaphorin-4A |
| NCBI Synonym Full Names: | semaphorin 4A |
| NCBI Official Symbol: | SEMA4A |
| NCBI Official Synonym Symbols: | RP35; SEMB; SEMAB; CORD10 |
| NCBI Protein Information: | semaphorin-4A |
| UniProt Protein Name: | Semaphorin-4A |
| UniProt Synonym Protein Names: | Semaphorin-B; Sema B |
| Protein Family: | Semaphorin |
| UniProt Gene Name: | SEMA4A |
| UniProt Entry Name: | SEM4A_HUMAN |