Anti-SEMA3A Antibody (CAB5700)
- SKU:
- CAB5700
- Product type:
- Antibody
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
| 抗体名: | Anti-SEMA3A Antibody |
| 抗体コード: | CAB5700 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-270 of human SEMA3A (NP_006071.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Rat |
| ポジティブサンプル: | Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-270 of human SEMA3A (NP_006071.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | ANYQ NGKN NVPR LKLS YKEM LESN NVIT FNGL ANSS SYHT FLLD EERS RLYV GAKD HIFS FDLV NIKD FQKI VWPV SYTR RDEC KWAG KDIL KECA NFIK VLKA YNQT HLYA CGTG AFHP ICTY IEIG HHPE DNIF KLEN SHFE NGRG KSPY DPKL LTAS LLID GELY SGTA ADFM GRDF AIFR TLGH HHPI RTEQ HDSR WLND PKFI SAHL ISES DNPE DDKV YFFF RENA IDGE HSGK ATHA RIGQ ICK |
| 遺伝子ID: | 10371 |
| Uniprot: | Q14563 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 88kDa |
| 観察された分子量: | 89KDa |
| 同義語: | SEMA3A, COLL1, HH16, Hsema-I, Hsema-III, SEMA1, SEMAD, SEMAIII, SEMAL, SemD, coll-1 |
| バックグラウンド: | This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. |
| UniProt Protein Function: | SEMA3A: Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1. Belongs to the semaphorin family. |
| UniProt Protein Details: | Protein type:Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide Chromosomal Location of Human Ortholog: 7p12.1 Cellular Component: axon; extracellular region; extracellular space Molecular Function:chemorepellent activity; semaphorin receptor binding Biological Process: axon extension involved in axon guidance; axon guidance; negative regulation of axon extension involved in axon guidance; nerve development; neural crest cell migration; neuron migration; olfactory bulb development; regulation of axon extension involved in axon guidance; sensory system development; sympathetic nervous system development Disease: Hypogonadotropic Hypogonadism 16 With Or Without Anosmia |
| NCBI Summary: | This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q14563 |
| NCBI GenInfo Identifier: | 8134674 |
| NCBI Gene ID: | 10371 |
| NCBI Accession: | Q14563.1 |
| UniProt Related Accession: | Q14563 |
| Molecular Weight: | |
| NCBI Full Name: | Semaphorin-3A |
| NCBI Synonym Full Names: | semaphorin 3A |
| NCBI Official Symbol: | SEMA3A |
| NCBI Official Synonym Symbols: | HH16; SemD; COLL1; SEMA1; SEMAD; SEMAL; coll-1; Hsema-I; SEMAIII; Hsema-III |
| NCBI Protein Information: | semaphorin-3A |
| UniProt Protein Name: | Semaphorin-3A |
| UniProt Synonym Protein Names: | Semaphorin III; Sema III |
| Protein Family: | Semaphorin |
| UniProt Gene Name: | SEMA3A |
| UniProt Entry Name: | SEM3A_HUMAN |
 | Western blot analysis of extracts of Rat brain, using SEMA3A antibody (CAB5700) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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