Anti-SEC63 Antibody (CAB20554)
- SKU:
- CAB20554
- Product type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ERdj2
- Synonyms:
- PCLD2
- Synonyms:
- SEC63L
- Synonyms:
- DNAJC23
- Synonyms:
- PRO2507
Frequently bought together:
Description
| 抗体名: | SEC63 Rabbit pAb |
| 抗体コード: | CAB20554 |
| サイズ: | 50uL, 100uL |
| 同義語: | ERdj2, PCLD2, SEC63L, DNAJC23, PRO2507 |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human SEC63. |
| 申し込み: | WB |
| 推奨される希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HepG2, Mouse liver, Mouse brain, Rat lung |
| 免疫原: | Recombinant protein of human SEC63. |
| 精製方法: | Affinity purification |
| 保管所: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 11231 |
| Uniprot: | Q9UGP8 |
| 計算された分子量: | 87kDa |
| 観察された分子量: | 100kDa |
| UniProt Protein Function: | SEC63: Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane. Defects in SEC63 are a cause of polycystic liver disease (PCLD). PCLD is an autosomal dominant disorder and is characterized by the presence of multiple liver cysts of biliary epithelial origin. Protein type: Membrane protein, integral; Endoplasmic reticulum; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 6q21 Cellular Component: cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; membrane Molecular Function: protein binding; receptor activity Biological Process: posttranslational protein targeting to membrane; protein targeting to membrane; SRP-dependent cotranslational protein targeting to membrane Disease: Polycystic Liver Disease |
| UniProt Protein Details: | |
| NCBI Summary: | The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UGP8 |
| NCBI GenInfo Identifier: | 18203500 |
| NCBI Gene ID: | 11231 |
| NCBI Accession: | Q9UGP8.2 |
| UniProt Secondary Accession: | Q9UGP8,O95380, Q5THN4, Q86VS9, Q8IWL0, Q9NTE0 |
| UniProt Related Accession: | Q9UGP8 |
| Molecular Weight: | 87,997 Da |
| NCBI Full Name: | Translocation protein SEC63 homolog |
| NCBI Synonym Full Names: | SEC63 homolog, protein translocation regulator |
| NCBI Official Symbol: | SEC63 |
| NCBI Official Synonym Symbols: | ERdj2; SEC63L; DNAJC23; PRO2507 |
| NCBI Protein Information: | translocation protein SEC63 homolog |
| UniProt Protein Name: | Translocation protein SEC63 homolog |
| UniProt Synonym Protein Names: | |
| Protein Family: | Translocation protein |
| UniProt Gene Name: | SEC63 |
| UniProt Entry Name: | SEC63_HUMAN |
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