Anti-SEC61A1 Antibody (CAB11658)
- SKU:
- CAB11658
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-SEC61A1 Antibody |
| 抗体コード: | CAB11658 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 310-420 of human SEC61A1 (NP_037468.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 293T, LO2, A-549, Mouse pancreas, Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 310-420 of human SEC61A1 (NP_037468.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | ARFS GNLL VSLL GTWS DTSS GGPA RAYP VGGL CYYL SPPE SFGS VLED PVHA VVYI VFML GSCA FFSK TWIE VSGS SAKD VAKQ LKEQ QMVM RGHR ETSM VHEL NRYI PTA |
| 遺伝子ID: | 29927 |
| Uniprot: | P61619 |
| セルラーロケーション: | Endoplasmic reticulum membrane, Multi-pass membrane protein |
| 計算された分子量: | 38kDa/52kDa |
| 観察された分子量: | 52kDa |
| 同義語: | SEC61A1, HNFJ4, HSEC61, SEC61, SEC61A |
| バックグラウンド: | The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. |
| UniProt Protein Function: | SEC61A1: Plays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane- bound ribosomes, either directly or through adapter proteins. Belongs to the SecY/SEC61-alpha family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 3q21.3 Cellular Component: cytosol; endoplasmic reticulum membrane; integral to endoplasmic reticulum membrane; membrane Molecular Function:protein binding; ribosome binding Biological Process: cell growth; endoplasmic reticulum organization and biogenesis; posttranslational protein targeting to membrane; protein targeting to ER; SRP-dependent cotranslational protein targeting to membrane Disease: Hyperuricemic Nephropathy, Familial Juvenile, 4 |
| NCBI Summary: | The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P61619 |
| NCBI GenInfo Identifier: | 48429109 |
| NCBI Gene ID: | 29927 |
| NCBI Accession: | P61619.2 |
| UniProt Secondary Accession: | P61619,P38378, P57726, Q5JPF8, Q8N0Z4, Q8N3U3, Q8NC71 Q9BU16, Q9Y2R3, |
| UniProt Related Accession: | P61619 |
| Molecular Weight: | 52kDa |
| NCBI Full Name: | Protein transport protein Sec61 subunit alpha isoform 1 |
| NCBI Synonym Full Names: | Sec61 translocon alpha 1 subunit |
| NCBI Official Symbol: | SEC61A1 |
| NCBI Official Synonym Symbols: | HNFJ4; SEC61; HSEC61; SEC61A |
| NCBI Protein Information: | protein transport protein Sec61 subunit alpha isoform 1 |
| UniProt Protein Name: | Protein transport protein Sec61 subunit alpha isoform 1 |
| Protein Family: | Protein transport protein |
| UniProt Gene Name: | SEC61A1 |
 | Western blot analysis of extracts of various cell lines, using SEC61A1 antibody (CAB11658) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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