Anti-SEC11A Antibody (CAB10552)
- SKU:
- CAB10552
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-SEC11A Antibody |
| 抗体コード: | CAB10552 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 37-145 of human SEC11A (NP_055115.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | SGC-7901, HT-29, Raji, HepG2, A-549, Mouse kidney, Mouse liver, Mouse lung, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 37-145 of human SEC11A (NP_055115.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | KGLM VITG SESP IVVV LSGS MEPA FHRG DLLF LTNR VEDP IRVG EIVV FRIE GREI PIVH RVLK IHEK QNGH IKFL TKGD NNAV DDRG LYKQ GQHW LEKK DVVG RARG F |
| 遺伝子ID: | 23478 |
| Uniprot: | P67812 |
| セルラーロケーション: | Endoplasmic reticulum membrane, Microsome membrane, Single-pass type II membrane protein |
| 計算された分子量: | 17kDa/18kDa/20kDa/21kDa |
| 観察された分子量: | 21kDa |
| 同義語: | SEC11A, 1810012E07Rik, SEC11L1, SPC18, SPCS4A, sid2895 |
| バックグラウンド: | This gene encodes a member of the peptidase S26B family. The encoded protein is an 18kDa subunit of the signal peptidase complex and has been linked to cell migration and invasion, gastric cancer and lymph node metastasis. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. |
| UniProt Protein Function: | SEC11A: Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Belongs to the peptidase S26B family. |
| UniProt Protein Details: | Protein type:EC 3.4.21.89; Membrane protein, integral; Protease Chromosomal Location of Human Ortholog: 15q25.2-q25.3 Cellular Component: endoplasmic reticulum membrane; signal peptidase complex Molecular Function:peptidase activity Biological Process: signal peptide processing |
| NCBI Summary: | This gene encodes a member of the peptidase S26B family. The encoded protein is an 18kDa subunit of the signal peptidase complex and has been linked to cell migration and invasion, gastric cancer and lymph node metastasis. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Dec 2012] |
| UniProt Code: | P67812 |
| NCBI GenInfo Identifier: | 54039634 |
| NCBI Gene ID: | 23478 |
| NCBI Accession: | P67812.1 |
| UniProt Secondary Accession: | P67812,O75957, P21378, Q53FQ8, B2RAD7, B4DUL4, H0YK72 H0YK83, |
| UniProt Related Accession: | P67812 |
| Molecular Weight: | 21kDa |
| NCBI Full Name: | Signal peptidase complex catalytic subunit SEC11A |
| NCBI Synonym Full Names: | SEC11 homolog A, signal peptidase complex subunit |
| NCBI Official Symbol: | SEC11A |
| NCBI Official Synonym Symbols: | SPC18; SPCS4A; SEC11L1; sid2895; 1810012E07Rik |
| NCBI Protein Information: | signal peptidase complex catalytic subunit SEC11A |
| UniProt Protein Name: | Signal peptidase complex catalytic subunit SEC11A |
| UniProt Synonym Protein Names: | Endopeptidase SP18; Microsomal signal peptidase 18 kDa subunit; SPase 18 kDa subunit; SEC11 homolog A; SEC11-like protein 1; SPC18 |
| Protein Family: | Signal peptidase complex |
| UniProt Gene Name: | SEC11A |
 | Western blot analysis of extracts of various cell lines, using SEC11A antibody (CAB10552) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunofluorescence analysis of L929 cells using SEC11A Rabbit pAb (CAB10552) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of U2OS cells using SEC11A Rabbit pAb (CAB10552) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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