Anti-SDCBP Antibody (CAB5360)
- SKU:
- CAB5360
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
抗体名: | Anti-SDCBP Antibody |
抗体コード: | CAB5360 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human SDCBP (NP_001007068.1). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human |
ポジティブサンプル: | HT-29, THP-1 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human SDCBP (NP_001007068.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MSLY PSLE DLKV DKVI QAQT AFSA NPAN PAIL SEAS APIP HDGN LYPR LYPE LSQY MGLS LNEE EIRA NVAV VSGA PLQG QLVA RPSS INYM VAPV TGND VGIR RAEI KQGI REVI LCKD QDGK IGLR LKSI DNGI FVQL VQAN SPAS LVGL RFGD QVLQ INGE NCAG WSSD KAHK VLKQ AFGE KITM TIRD RPFE RTIT MHKD STGH VGFI FKNG KITS IVKD SSAA RNGL LTEH NICE INGQ NVIG LKDS QIAD ILST |
遺伝子ID: | 6386 |
Uniprot: | O00560 |
セルラーロケーション: | Cell junction, Cell membrane, Cytoplasm, Endoplasmic reticulum membrane, Melanosome, Nucleus, Peripheral membrane protein, adherens junction, cytoskeleton, cytosol, focal adhesion |
計算された分子量: | 31kDa/32kDa |
観察された分子量: | 32kDa |
同義語: | SDCBP, MDA-9, MDA9, ST1, SYCL, TACIP18 |
バックグラウンド: | The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. Related pseudogenes have been identified on multiple chromosomes. |
UniProt Protein Function: | syntenin: Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cytokine; Adaptor/scaffold; Vesicle; Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 8q12 Cellular Component: extracellular space; endoplasmic reticulum membrane; focal adhesion; cytosol; adherens junction; cytoskeleton; membrane; cytoplasm; plasma membrane; melanosome; interleukin-5 receptor complex; nucleus; vesicle Molecular Function:syndecan binding; protein C-terminus binding; identical protein binding; protein homodimerization activity; ephrin receptor binding; protein N-terminus binding; protein binding; interleukin-5 receptor binding; protein heterodimerization activity; frizzled binding; neurexin binding; growth factor binding; cytoskeletal adaptor activity; cell adhesion molecule binding; glycoprotein binding Biological Process: synaptic transmission; axon guidance; Ras protein signal transduction; ephrin receptor signaling pathway; positive regulation of JNK cascade; actin cytoskeleton organization and biogenesis; protein targeting to membrane; substrate-bound cell migration, cell extension; positive regulation of phosphorylation |
NCBI Summary: | The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. Related pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Jan 2017] |
UniProt Code: | O00560 |
NCBI GenInfo Identifier: | 20455281 |
NCBI Gene ID: | 6386 |
NCBI Accession: | O00560.1 |
UniProt Related Accession: | O00560 |
Molecular Weight: | |
NCBI Full Name: | Syntenin-1 |
NCBI Synonym Full Names: | syndecan binding protein |
NCBI Official Symbol: | SDCBP |
NCBI Official Synonym Symbols: | ST1; MDA9; SYCL; MDA-9; TACIP18 |
NCBI Protein Information: | syntenin-1 |
UniProt Protein Name: | Syntenin-1 |
UniProt Synonym Protein Names: | Melanoma differentiation-associated protein 9; MDA-9; Pro-TGF-alpha cytoplasmic domain-interacting protein 18; TACIP18; Scaffold protein Pbp1; Syndecan-binding protein 1 |
Protein Family: | High affinity sulfate transporter |
UniProt Gene Name: | SDCBP |
UniProt Entry Name: | SDCB1_HUMAN |