Anti-SCYL1 Antibody (CAB19913)[KO Validated]
![Anti-SCYL1 Antibody (CAB19913)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/608x608/products/28202/28050/anti-scyl1-antibody-cab19913ko-validated__26462__14145.1645806987.jpg?c=1 "Anti-SCYL1 Antibody (CAB19913)[KO Validated]")
- SKU:
- CAB19913
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
![Anti-SCYL1 Antibody (CAB19913)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/1280x1280/products/28202/28050/anti-scyl1-antibody-cab19913ko-validated__26462__14145.1645806987.jpg?c=1&imbypass=on "Anti-SCYL1 Antibody (CAB19913)[KO Validated]")
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Description
| 抗体名: | Anti-SCYL1 Antibody [KO Validated] |
| 抗体コード: | CAB19913 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human SCYL1. |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 293T |
| 免疫原: | Recombinant protein of human SCYL1. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 57410 |
| Uniprot: | Q96KG9 |
| セルラーロケーション: | Cytoplasm, Endoplasmic reticulum-Golgi intermediate compartment, Golgi apparatus, Nucleus, centrosome, cis-Golgi network, cytoskeleton, microtubule organizing center |
| 計算された分子量: | 69kDa/78kDa/86kDa/88kDa/89kDa |
| 観察された分子量: | 105KDa |
![Anti-SCYL1 Antibody [KO Validated] (CAB19913)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/d/337/A19913_1__80075.jpg) | Western blot analysis of extracts from normal (control) and SCYL1 knockout (KO) 293T cells, using SCYL1 antibody (CAB19913) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
| 同義語: | SCYL1, GKLP, HT019, NKTL, NTKL, P105, SCAR21, TAPK, TEIF, TRAP |
| バックグラウンド: | This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | SCYL1: Regulates COPI-mediated retrograde traffic. Has no detectable kinase activity in vitro. Belongs to the protein kinase superfamily. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Other group; SCY1 family Chromosomal Location of Human Ortholog: 11q13 Cellular Component: Golgi apparatus; cis-Golgi network; membrane; cytoplasm; ER-Golgi intermediate compartment; microtubule organizing center; COPI vesicle coat; nucleus Molecular Function:DNA binding; protein-tyrosine kinase activity; ATP binding Biological Process: peptidyl-tyrosine phosphorylation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; retrograde vesicle-mediated transport, Golgi to ER |
| NCBI Summary: | This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96KG9 |
| NCBI GenInfo Identifier: | 74762671 |
| NCBI Gene ID: | 57410 |
| NCBI Accession: | Q96KG9.1 |
| UniProt Secondary Accession: | Q96KG9,Q96G50, Q96KG8, Q96KH1, Q9HAW5, Q9HBL3, Q9NR53 A6NJF1, |
| UniProt Related Accession: | Q96KG9 |
| Molecular Weight: | 808 |
| NCBI Full Name: | N-terminal kinase-like protein |
| NCBI Synonym Full Names: | SCY1-like 1 (S. cerevisiae) |
| NCBI Official Symbol: | SCYL1 |
| NCBI Official Synonym Symbols: | GKLP; NKTL; NTKL; P105; TAPK; TEIF; TRAP; HT019 |
| NCBI Protein Information: | N-terminal kinase-like protein; SCY1-like protein 1; teratoma-associated tyrosine kinase; telomerase regulation-associated protein; coated vesicle-associated kinase of 90 kDa; telomerase transcriptional element-interacting factor; telomerase transcriptional elements-interacting factor; likely ortholog of mouse N-terminal kinase-like protein |
| UniProt Protein Name: | N-terminal kinase-like protein |
| UniProt Synonym Protein Names: | Coated vesicle-associated kinase of 90 kDa; SCY1-like protein 1; Telomerase regulation-associated protein; Telomerase transcriptional element-interacting factor; Teratoma-associated tyrosine kinase |
| Protein Family: | N-terminal kinase-like protein |
| UniProt Gene Name: | SCYL1 |
| UniProt Entry Name: | NTKL_HUMAN |