Anti-SCP2 Antibody (CAB5382)
- SKU:
- CAB5382
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-SCP2 Antibody |
| 抗体コード: | CAB5382 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-322 of human SCP2 (NP_001007099.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | Mouse liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-322 of human SCP2 (NP_001007099.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MSSS PWEP ATLR RVFV VGVG MTKF VKPG AENS RDYP DLAE EAGK KALA DAQI PYSA VDQA CVGY VFGV AECV LALG FEKM SKGS LGIK FSDR TIPT DKHV DLLI NKYG LSAH PVAP QMFG YAGK EHME KYGT KIEH FAKI GWKN HKHS VNNP YSQF QDEY SLDE VMAS KEVF DFLT ILQC CPTS DGAA AAIL ASEA FVQK YGLQ SKAV EILA QEMM TDLP SSFE EKSI IKMV GFDM SKEA ARKC YEKS GLTP NDID VIEL HDCF STNE LLTY EALG LCPE GQGA TLVD RGDN TYGG KWVI NPSG GLIS KGHP LGAT GGHS CS |
| 遺伝子ID: | 6342 |
| Uniprot: | P22307 |
| セルラーロケーション: | Cytoplasm, Mitochondrion, Mitochondrion, Peroxisome |
| 計算された分子量: | 6kDa/15kDa/34kDa/50kDa/54kDa/56kDa/58kDa |
| 観察された分子量: | 59kDa |
| 同義語: | SCP2, NLTP, NSL-TP, SCP-2, SCP-CHI, SCP-X, SCPX |
| バックグラウンド: | This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. |
| UniProt Protein Function: | SCP2: Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis. Defects in SCP2 are a cause of leukoencephalopathy with dystonia and motor neuropathy (LDMN); also known as sterol carrier protein 2 deficiency. LDMN is a syndrome characterized by leukoencephalopathy, dystonic head tremor, spasmodic torticollis and reduced tendon reflexes in lower extremities. Additional features include hyposmia, pathologic saccadic eye movements, a slight hypoacusis, accumulation of branched-chain pristanic acid in plasma, and the presence of abnormal bile alcohol glucuronides in urine. 3 isoforms of the human protein are produced by alternative promoter. |
| UniProt Protein Details: | Protein type:Transferase; EC 2.3.1.176; Mitochondrial; Lipid Metabolism - primary bile acid biosynthesis; Lipid-binding Chromosomal Location of Human Ortholog: 1p32 Cellular Component: cytoplasm; intracellular membrane-bound organelle; membrane; nucleoplasm; peroxisomal matrix; peroxisome; protein complex Molecular Function:acyl-CoA binding; cholesterol binding; propionyl-CoA C2-trimethyltridecanoyltransferase activity; protein binding; receptor binding; sterol transporter activity Biological Process: bile acid biosynthetic process; fatty acid beta-oxidation using acyl-CoA oxidase; positive regulation of intracellular cholesterol transport Disease: Leukoencephalopathy With Dystonia And Motor Neuropathy |
| NCBI Summary: | This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.[provided by RefSeq, Aug 2010] |
| UniProt Code: | P22307 |
| NCBI GenInfo Identifier: | 2507456 |
| NCBI Gene ID: | 6342 |
| NCBI Accession: | P22307.2 |
| UniProt Secondary Accession: | P22307,Q15432, Q16622, Q5VVZ1, Q6NXF4, A6NM69, B4DGJ9 B4DHP6, C9JC79, D3DQ37, E1B6W5, F2Z3J1, |
| UniProt Related Accession: | P22307 |
| Molecular Weight: | 56,497 Da |
| NCBI Full Name: | Non-specific lipid-transfer protein |
| NCBI Synonym Full Names: | sterol carrier protein 2 |
| NCBI Official Symbol: | SCP2 |
| NCBI Official Synonym Symbols: | NLTP; SCPX; SCP-2; SCP-X; NSL-TP; SCP-CHI |
| NCBI Protein Information: | non-specific lipid-transfer protein |
| UniProt Protein Name: | Non-specific lipid-transfer protein |
| UniProt Synonym Protein Names: | Propanoyl-CoA C-acyltransferase; SCP-chi; SCPX; Sterol carrier protein 2; SCP-2; Sterol carrier protein X; SCP-X |
| Protein Family: | SCP2 sterol-binding domain-containing protein |
| UniProt Gene Name: | SCP2 |
| UniProt Entry Name: | NLTP_HUMAN |
 | Western blot analysis of extracts of mouse liver, using SCP2 Antibody (CAB5382) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human liver cancer using SCP2 antibody (CAB5382) at dilution of 1:200 (40x lens). |
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