Anti-SCO2 Antibody (CAB7051)
- SKU:
- CAB7051
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-SCO2 Antibody |
| 抗体コード: | CAB7051 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human SCO2 (NP_001162582.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 293T, HL-60, SKOV3, Mouse spleen, Mouse brain, Rat spleen |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human SCO2 (NP_001162582.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MLLL TRSP TAWH RLSQ LKPR VLPG TLGG QALH LRSW LLSR QGPA ETGG QGQP QGPG LRTR LLIT GLFG AGLG GAWL ALRA EKER LQQQ KRTE ALRQ AAVG QGDF HLLD HRGR ARCK ADFR GQWV LMYF GF |
| 遺伝子ID: | 9997 |
| Uniprot: | O43819 |
| セルラーロケーション: | Mitochondrion |
| 計算された分子量: | 29kDa |
| 観察された分子量: | 30kDa |
| 同義語: | SCO2, CEMCOX1, MYP6, SCO1L |
| バックグラウンド: | Cytochrome c oxidase (COX) catalyzes the transfer of electrons from cytochrome c to molecular oxygen, which helps to maintain the proton gradient across the inner mitochondrial membrane that is necessary for aerobic ATP production. Human COX is a multimeric protein complex that requires several assembly factors; this gene encodes one of the COX assembly factors. The encoded protein is a metallochaperone that is involved in the biogenesis of cytochrome c oxidase subunit II. Mutations in this gene are associated with fatal infantile encephalocardiomyopathy and myopia 6. |
| UniProt Protein Function: | SCO2: Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2). Defects in SCO2 are the cause of fatal infantile cardioencephalomyopathy with cytochrome c oxidase deficiency (FIC). This disease is characterized by hypertrophic cardiomyopathy, lactic acidosis, and gliosis. Heart and skeletal muscle show reductions in cytochrome c oxidase (COX) activity, whereas liver and fibroblasts show mild COX deficiencies. Belongs to the SCO1/2 family. |
| UniProt Protein Details: | Protein type:Mitochondrial Chromosomal Location of Human Ortholog: 22q13.33 Cellular Component: nucleoplasm; myofibril; mitochondrion; mitochondrial inner membrane Molecular Function:copper ion binding Biological Process: cellular copper ion homeostasis; eye development; in utero embryonic development; respiratory chain complex IV assembly; response to activity; muscle system process; copper ion transport Disease: Cardioencephalomyopathy, Fatal Infantile, Due To Cytochrome C Oxidase Deficiency 1; Myopia 6 |
| NCBI Summary: | Cytochrome c oxidase (COX) catalyzes the transfer of electrons from cytochrome c to molecular oxygen, which helps to maintain the proton gradient across the inner mitochondrial membrane that is necessary for aerobic ATP production. Human COX is a multimeric protein complex that requires several assembly factors; this gene encodes one of the COX assembly factors. The encoded protein is a metallochaperone that is involved in the biogenesis of cytochrome c oxidase subunit II. Mutations in this gene are associated with fatal infantile encephalocardiomyopathy and myopia 6. [provided by RefSeq, Oct 2014] |
| UniProt Code: | O43819 |
| NCBI GenInfo Identifier: | 8134662 |
| NCBI Gene ID: | 9997 |
| NCBI Accession: | O43819.3 |
| UniProt Secondary Accession: | O43819,Q3T1B5, Q9UK87, |
| UniProt Related Accession: | O43819 |
| Molecular Weight: | 29,810 Da |
| NCBI Full Name: | Protein SCO2 homolog, mitochondrial |
| NCBI Synonym Full Names: | SCO2 cytochrome c oxidase assembly protein |
| NCBI Official Symbol: | SCO2 |
| NCBI Official Synonym Symbols: | MYP6; SCO1L; CEMCOX1 |
| NCBI Protein Information: | protein SCO2 homolog, mitochondrial; SCO cytochrome oxidase deficient homolog 2 |
| UniProt Protein Name: | Protein SCO2 homolog, mitochondrial |
| Protein Family: | SCO2-like protein |
| UniProt Gene Name: | SCO2 |
| UniProt Entry Name: | SCO2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SCO2 antibody (CAB7051) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 3min. |
 | Immunohistochemistry of paraffin-embedded Human colon using SCO2 Rabbit pAb (CAB7051) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded Rat ovary using SCO2 Rabbit pAb (CAB7051) at dilution of 1:100 (40x lens). |
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