Anti-SCN3B Antibody (CAB10316)
- SKU:
- CAB10316
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-SCN3B Antibody |
| 抗体コード: | CAB10316 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-160 of human SCN3B (NP_060870.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | U-87MG, A-549, B cells, Mouse lung, Mouse liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-160 of human SCN3B (NP_060870.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | FPVC VEVP SETE AVQG NPMK LRCI SCMK REEV EATT VVEW FYRP EGGK DFLI YEYR NGHQ EVES PFQG RLQW NGSK DLQD VSIT VLNV TLND SGLY TCNV SREF EFEA HRPF VKTT RLIP LRVT EEAG EDFT SVVS EI |
| 遺伝子ID: | 55800 |
| Uniprot: | Q9NY72 |
| セルラーロケーション: | Membrane, Single-pass type I membrane protein |
| 計算された分子量: | 24kDa |
| 観察された分子量: | 30kDa |
| 同義語: | SCN3B, ATFB16, BRGDA7, HSA243396, SCNB3 |
| バックグラウンド: | Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified. |
| UniProt Protein Function: | SCN3B: Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. Defects in SCN3B are the cause of Brugada syndrome type 7 (BRGDA7). A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family. |
| UniProt Protein Details: | Protein type:Channel, sodium; Membrane protein, integral Chromosomal Location of Human Ortholog: 11q24.1 Cellular Component: plasma membrane; voltage-gated sodium channel complex; Z disc Molecular Function:sodium channel regulator activity Biological Process: cardiac muscle contraction; membrane depolarization; positive regulation of heart rate Disease: Brugada Syndrome 7 |
| NCBI Summary: | Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NY72 |
| NCBI GenInfo Identifier: | 12229762 |
| NCBI Gene ID: | 55800 |
| NCBI Accession: | Q9NY72.1 |
| UniProt Secondary Accession: | Q9NY72,Q17RL3, Q9ULR2, A5H1I5, |
| UniProt Related Accession: | Q9NY72 |
| Molecular Weight: | Calculated: 24kDaObserved: 30kDa |
| NCBI Full Name: | Sodium channel subunit beta-3 |
| NCBI Synonym Full Names: | sodium voltage-gated channel beta subunit 3 |
| NCBI Official Symbol: | SCN3B |
| NCBI Official Synonym Symbols: | SCNB3; ATFB16; BRGDA7; HSA243396 |
| NCBI Protein Information: | sodium channel subunit beta-3 |
| UniProt Protein Name: | Sodium channel subunit beta-3 |
| Protein Family: | Sodium channel |
| UniProt Gene Name: | SCN3B |
 | Western blot analysis of extracts of various cell lines, using SCN3B antibody (CAB10316) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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