Anti-SCN1B Antibody (CAB10071)
- SKU:
- CAB10071
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-SCN1B Antibody |
| 抗体コード: | CAB10071 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-160 of human SCN1B (NP_950238.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | SH-SY5Y, A-549, HeLa, MCF7, Mouse brain, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-160 of human SCN1B (NP_950238.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | GGCV EVDS ETEA VYGM TFKI LCIS CKRR SETN AETF TEWT FRQK GTEE FVKI LRYE NEVL QLEE DERF EGRV VWNG SRGT KDLQ DLSI FITN VTYN HSGD YECH VYRL LFFE NYEH NTSV VKKI HIEV VDKG ESGA ACPF TV |
| 遺伝子ID: | 6324 |
| Uniprot: | Q07699 |
| セルラーロケーション: | Membrane, Secreted, Single-pass type I membrane protein |
| 計算された分子量: | 24kDa/30kDa |
| 観察された分子量: | 30kDa |
| 同義語: | SCN1B, ATFB13, BRGDA5, EIEE52, GEFSP1 |
| バックグラウンド: | Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | SCN1B: Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. Defects in SCN1B are the cause of generalized epilepsy with febrile seizures plus type 1 (GEFS+1). Generalized epilepsy with febrile seizures-plus refers to a rare autosomal dominant, familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. GEFS+ is a disease combining febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity. Defects in SCN1B are the cause of Brugada syndrome type 5 (BRGDA5). A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the sodium channel auxiliary subunit SCN1B (TC 8.A.17) family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Channel, sodium Chromosomal Location of Human Ortholog: 19q13.1 Cellular Component: voltage-gated sodium channel complex; T-tubule; extracellular region Molecular Function:sodium channel inhibitor activity; sodium channel regulator activity; voltage-gated sodium channel activity Biological Process: synaptic transmission; membrane depolarization; axon guidance; action potential propagation; corticospinal neuron axon guidance; cell adhesion; locomotion; response to pyrethroid; cardiac muscle contraction Disease: Generalized Epilepsy With Febrile Seizures Plus, Type 1; Atrial Fibrillation, Familial, 13; Brugada Syndrome 5 |
| NCBI Summary: | Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009] |
| UniProt Code: | Q07699 |
| NCBI GenInfo Identifier: | 1705868 |
| NCBI Gene ID: | 6324 |
| NCBI Accession: | Q07699.1 |
| UniProt Related Accession: | Q07699 |
| Molecular Weight: | |
| NCBI Full Name: | Sodium channel subunit beta-1 |
| NCBI Synonym Full Names: | sodium voltage-gated channel beta subunit 1 |
| NCBI Official Symbol: | SCN1B |
| NCBI Official Synonym Symbols: | ATFB13; BRGDA5; EIEE52; GEFSP1 |
| NCBI Protein Information: | sodium channel subunit beta-1 |
| UniProt Protein Name: | Sodium channel subunit beta-1 |
| Protein Family: | Sodium channel |
| UniProt Gene Name: | SCN1B |
| UniProt Entry Name: | SCN1B_HUMAN |
 | Western blot analysis of extracts of various cell lines, using SCN1B antibody (CAB10071) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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