Anti-SCIN Antibody (CAB17800)
- SKU:
- CAB17800
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-SCIN Antibody |
| 抗体コード: | CAB17800 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide of Human SCIN. |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | HT-29, SGC-7901 |
| 免疫原: | A synthetic peptide of Human SCIN. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 85477 |
| Uniprot: | Q9Y6U3 |
| セルラーロケーション: | |
| 計算された分子量: | 52kDa/65kDa/80kDa |
| 観察された分子量: | 80kDa |
 | Western blot - SCIN Polyclonal Antibody (CAB17800) |
| 同義語: | SCIN, adseverin |
| バックグラウンド: | SCIN is a Ca(2+)-dependent actin-severing and -capping protein (Zunino et al., 2001 [PubMed 11568009]).[supplied by OMIM, May 2010] |
| UniProt Protein Function: | SCIN: Ca(2+)-dependent actin filament-severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Regulates chondrocyte proliferation and differentiation. MAP kinases p38 and ERK1/2 mediate the adseverin-induced accelerated differentiation of non-hypertrophic chondrocytes. Belongs to the villin/gelsolin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 7p21.3 Cellular Component: protein complex; cytoskeleton; cytoplasm; cell cortex Molecular Function:actin filament binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylserine binding; calcium ion binding; actin binding; phosphatidylinositol binding Biological Process: negative regulation of cell proliferation; actin filament severing; positive regulation of apoptosis; actin filament capping; positive regulation of secretion; positive regulation of megakaryocyte differentiation; regulation of chondrocyte differentiation; actin nucleation; calcium ion-dependent exocytosis |
| NCBI Summary: | SCIN is a Ca(2+)-dependent actin-severing and -capping protein (Zunino et al., 2001 [PubMed 11568009]).[supplied by OMIM, May 2010] |
| UniProt Code: | Q9Y6U3 |
| NCBI GenInfo Identifier: | 57015325 |
| NCBI Gene ID: | 85477 |
| NCBI Accession: | Q9Y6U3.4 |
| UniProt Secondary Accession: | Q9Y6U3,Q8NBZ6, Q8WU97, Q96JC7, Q96PY2, A8K2U8, |
| UniProt Related Accession: | Q9Y6U3 |
| Molecular Weight: | 715 |
| NCBI Full Name: | Adseverin |
| NCBI Synonym Full Names: | scinderin |
| NCBI Official Symbol: | SCIN |
| NCBI Protein Information: | adseverin |
| UniProt Protein Name: | Adseverin |
| UniProt Synonym Protein Names: | Scinderin |
| Protein Family: | Adseverin |
| UniProt Gene Name: | SCIN |
| UniProt Entry Name: | ADSV_HUMAN |