Anti-SBDS Antibody (CAB0796)

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SKU:
CAB0796
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
SBDS
Synonyms:
CGI-97
Synonyms:
SDS
Synonyms:
SWDS
Synonyms:
ribosome maturation protein SBDS
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Description

抗体名:SBDS Rabbit mAb
抗体コード:CAB0796
サイズ:20uL, 50uL, 100uL
同義語:SBDS, CGI-97, SDS, SWDS, ribosome maturation protein SBDS
申し込み:WB
反応性:Human, Mouse, Rat
宿主種:Rabbit
免疫原:A synthesized peptide derived from human SBDS.
申し込み:WB
推奨される希釈:WB 1:500 - 1:2000
反応性:Human, Mouse, Rat
ポジティブサンプル:TE-1, HepG2, SKOV3, Mouse lung, Mouse liver, Mouse brain, Mouse heart, Rat lung, Rat kidney
免疫原:A synthesized peptide derived from human SBDS.
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:51119
Uniprot:Q9Y3A5
セルラーロケーション:Cytoplasm, Nucleus, cytoskeleton, nucleolus, nucleoplasm, spindle
計算された分子量:29kDa
観察された分子量:29KDa
UniProt Protein Function:SBDS: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, triggers the GTP- dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. Defects in SBDS are the cause of Shwachman-Diamond syndrome (SDS). SDS is an autosomal recessive disorder characterized by pancreatic exocrine insufficiency, hematologic dysfunction, and skeletal abnormalities. Belongs to the SDO1/SBDS family.
UniProt Protein Details:

Protein type:Nucleolus

Chromosomal Location of Human Ortholog: 7q11.21

Cellular Component: nucleoplasm; spindle pole; cytoplasm; nucleolus; nucleus

Molecular Function:rRNA binding; protein binding; microtubule binding; ribosome binding

Biological Process: bone marrow development; cell proliferation; leukocyte chemotaxis; ribosomal large subunit biogenesis and assembly; inner cell mass cell proliferation; mitotic spindle stabilization; bone mineralization; rRNA processing; mature ribosome assembly

Disease: Shwachman-diamond Syndrome; Aplastic Anemia

NCBI Summary:This gene encodes a member of a highly conserved protein family that exists from archaea to vertebrates and plants. The encoded protein may function in RNA metabolism. Mutations within this gene are associated with Shwachman-Bodian-Diamond syndrome. An alternative transcript has been described, but its biological nature has not been determined. This gene has a closely linked pseudogene that is distally located. [provided by RefSeq, Jul 2008]
UniProt Code:Q9Y3A5
NCBI GenInfo Identifier:28380824
NCBI Gene ID:51119
NCBI Accession:Q9Y3A5.4
UniProt Secondary Accession:Q9Y3A5,Q96FX0, Q9NV53, A8K0P4,
UniProt Related Accession:Q9Y3A5
Molecular Weight:250
NCBI Full Name:Ribosome maturation protein SBDS
NCBI Synonym Full Names:Shwachman-Bodian-Diamond syndrome
NCBI Official Symbol:SBDS  
NCBI Official Synonym Symbols:SDS; SWDS; CGI-97  
NCBI Protein Information:ribosome maturation protein SBDS
UniProt Protein Name:Ribosome maturation protein SBDS
UniProt Synonym Protein Names:Shwachman-Bodian-Diamond syndrome protein
Protein Family:Ribosome maturation protein
UniProt Gene Name:SBDS  
UniProt Entry Name:SBDS_HUMAN
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