Anti-SARS-CoV-2 Spike Antibody, S1 Monoclonal (CAB20022)

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SKU:
CAB20022
Product type:
Antibody
Reactivity:
SARS-CoV-2
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
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Description

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抗体名:SARS-CoV-2 spike antibody, S1 Monoclonal
抗体コード:CAB20022
抗体サイズ:50uL, 100uL
申し込み:ELISA, FC, IHC, IF, IP
反応性:SARS-CoV-2
宿主種:Rabbit
免疫原:Recombinant fusion protein of 2019-nCoV Spike S1.
申し込み:ELISA, FC, IHC, IF, IP
推奨希釈:ELISA 1:1000 - 1:5000
FC 1:50 - 1:200
IHC 1:50 - 1:200
IF 1:50 - 1:200
IP 1:50 - 1:200
反応性:SARS-CoV-2
ポジティブサンプル:
免疫原:Recombinant fusion protein of 2019-nCoV Spike S1.
精製方法:Affinity purification
ストレージバッファ:Store at 4°C. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence.
遺伝子ID:43740568
Uniprot:P0DTC2
セルラーロケーション:Accumulates in the endoplasmic reticulum-Golgi intermediate compartment, where it participates in virus particle assembly. Colocalizes with S in the host endoplasmic reticulum-Golgi intermediate compartment. Some S oligomers are transported to the host plasma membrane, where they may mediate cell-cell fusion (By similarity).
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バックグラウンド:The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.
UniProt Protein Function:
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NCBI Summary:
UniProt Code:P0DTC2
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UniProt Secondary Accession:P0DTC2
UniProt Related Accession:P0DTC2
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Protein Family:SMY2
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