Anti-SARDH Antibody (CAB9541)
- SKU:
- CAB9541
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-SARDH Antibody |
抗体コード: | CAB9541 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-560 of human SARDH (NP_009032.2). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
反応性: | Mouse, Rat |
ポジティブサンプル: | Mouse brain, Mouse liver, Rat liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-560 of human SARDH (NP_009032.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | RIEG IQNM PNVR DHDA SVYL RLQG DALS VGGY EANP IFWE EVSD KFAF GLFD LDWE VFTQ HIEG AINR VPVL EKTG IKST VCGP ESFT PDHK PLMG EAPE LRGF FLGC GFNS AGMM LGGG CGQE LAHW IIHG RPEK DMHG YDIR RFHH SLTD HPRW IRER SHES YAKN YSVV FPHD EPLA GRNM RRDP LHEE LLGQ GCVF QERH GWER PGWF HPRG PAPV LEYD YYGA YGSR AHED YAYR RLLA DEYT FAFP PHHD TIKK E |
遺伝子ID: | 1757 |
Uniprot: | Q9UL12 |
セルラーロケーション: | Mitochondrion matrix |
計算された分子量: | 82kDa/101kDa |
観察された分子量: | 101kDa |
同義語: | SARDH, BPR-2, DMGDHL1, SAR, SARD, SDH |
バックグラウンド: | This gene encodes an enzyme localized to the mitochondrial matrix which catalyzes the oxidative demethylation of sarcosine. This enzyme is distinct from another mitochondrial matrix enzyme, dimethylglycine dehydrogenase, which catalyzes a reaction resulting in the formation of sarcosine. Mutations in this gene are associated with sarcosinemia. Alternatively spliced transcript variants have been described. |
UniProt Protein Function: | SARDH: Defects in SARDH are a cause of sarcosinemia (SAR). Sarcosinemia is a metabolic disorder characterized by an increased concentration of sarcosine in plasma and urine due to sarcosine dehydrogenase deficiency. Prevalence has been estimated at 1:28'000 to 1:350'000 in newborn screening programs. Sarcosinemia is most probably a benign condition without significant clinical problems. It is transmitted in an autosomal recessive manner. Belongs to the GcvT family. |
UniProt Protein Details: | Protein type:Amino Acid Metabolism - glycine, serine and threonine; Oxidoreductase; EC 1.5.8.3; Mitochondrial Chromosomal Location of Human Ortholog: 9q33-q34 Cellular Component: mitochondrion; mitochondrial matrix Molecular Function:sarcosine dehydrogenase activity Disease: Sarcosinemia |
NCBI Summary: | This gene encodes an enzyme localized to the mitochondrial matrix which catalyzes the oxidative demethylation of sarcosine. This enzyme is distinct from another mitochondrial matrix enzyme, dimethylglycine dehydrogenase, which catalyzes a reaction resulting in the formation of sarcosine. Mutations in this gene are associated with sarcosinemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2008] |
UniProt Code: | Q9UL12 |
NCBI GenInfo Identifier: | 21361378 |
NCBI Gene ID: | 1757 |
NCBI Accession: | NP_009032.2 |
UniProt Related Accession: | Q9UL12 |
Molecular Weight: | 105kDa |
NCBI Full Name: | sarcosine dehydrogenase, mitochondrial |
NCBI Synonym Full Names: | sarcosine dehydrogenase |
NCBI Official Symbol: | SARDH |
NCBI Official Synonym Symbols: | SAR; SDH; SARD; BPR-2; DMGDHL1 |
NCBI Protein Information: | sarcosine dehydrogenase, mitochondrial |
UniProt Protein Name: | Sarcosine dehydrogenase, mitochondrial |
UniProt Synonym Protein Names: | BPR-2 |
Protein Family: | Sarcosine dehydrogenase |
UniProt Gene Name: | SARDH |
UniProt Entry Name: | SARDH_HUMAN |
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