Anti-SAP30 Antibody (CAB17032)
- SKU:
- CAB17032
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-SAP30 Antibody |
抗体コード: | CAB17032 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human SAP30 (NP_003855.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: |
免疫原: | A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human SAP30 (NP_003855.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | IELD KSAR HLYI CDYH KNLI QSVR NRRK RKGS DDDG GDSP VQDI DTPE VDLY QLQV NTLR RYKR HFKL PTRP GLNK AQLV EIVG CHFR SIPV NEKD TLTY FIYS VKND KNKS DLKV DSGV H |
遺伝子ID: | 8819 |
Uniprot: | O75446 |
セルラーロケーション: | |
計算された分子量: | |
観察された分子量: | Refer to figures |
同義語: | SAP30 |
バックグラウンド: | Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. |
UniProt Protein Function: | SAP30: Involved in the functional recruitment of the Sin3- histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N- CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones. Belongs to the SAP30 family. |
UniProt Protein Details: | Protein type:Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 4q34.1 Cellular Component: histone deacetylase complex; nucleoplasm Molecular Function:histone deacetylase activity; protein binding; transcription corepressor activity Biological Process: regulation of transcription, DNA-dependent |
NCBI Summary: | Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Jul 2008] |
UniProt Code: | O75446 |
NCBI GenInfo Identifier: | 68053249 |
NCBI Gene ID: | 8819 |
NCBI Accession: | O75446.1 |
UniProt Secondary Accession: | O75446,D3DP38, |
UniProt Related Accession: | O75446 |
Molecular Weight: | 23,306 Da |
NCBI Full Name: | Histone deacetylase complex subunit SAP30 |
NCBI Synonym Full Names: | Sin3A associated protein 30 |
NCBI Official Symbol: | SAP30 |
NCBI Protein Information: | histone deacetylase complex subunit SAP30 |
UniProt Protein Name: | Histone deacetylase complex subunit SAP30 |
UniProt Synonym Protein Names: | 30 kDa Sin3-associated polypeptide; Sin3 corepressor complex subunit SAP30; Sin3-associated polypeptide p30 |
Protein Family: | SAP30-binding protein |
UniProt Gene Name: | SAP30 |
UniProt Entry Name: | SAP30_HUMAN |