Anti-RRAS2 Antibody (CAB7076)
- SKU:
- CAB7076
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-RRAS2 Antibody |
| 抗体コード: | CAB7076 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-204A of human RRAS2 (NP_036382.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HT-29, SKOV3, NIH/3T3, Mouse kidney, Mouse heart, Mouse lung, Rat kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-204A of human RRAS2 (NP_036382.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAAA GWRD GSGQ EKYR LVVV GGGG VGKS ALTI QFIQ SYFV TDYD PTIE DSYT KQCV IDDR AARL DILD TAGQ EEFG AMRE QYMR TGEG FLLV FSVT DRGS FEEI YKFQ RQIL RVKD RDEF PMIL IGNK ADLD HQRQ VTQE EGQQ LARQ LKVT YMEA SAKI RMNV DQAF HELV RVIR KFQE QECP PSPE PTRK EKDK KGCH CVIF |
| 遺伝子ID: | 22800 |
| Uniprot: | P62070 |
| セルラーロケーション: | Cell membrane, Cytoplasmic side, Lipid-anchor |
| 計算された分子量: | 15kDa/19kDa/23kDa/24kDa |
| 観察された分子量: | 23kDa |
| 同義語: | RRAS2, TC21 |
| バックグラウンド: | This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathways that control cell proliferation. Mutations in this gene are associated with the growth of certain tumors. Pseudogenes of this gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | RRAS2: It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion. Defects in RRAS2 are a cause of susceptibility to ovarian cancer (OC). The term ovarian cancer defines common malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. Belongs to the small GTPase superfamily. Ras family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:G protein; Oncoprotein; G protein, monomeric, Ras; G protein, monomeric; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11p15.2 Cellular Component: focal adhesion; membrane; endoplasmic reticulum; plasma membrane Molecular Function:GTPase activity; protein binding; GTP binding Biological Process: osteoblast differentiation; metabolic process; Ras protein signal transduction; positive regulation of cell migration |
| NCBI Summary: | This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathways that control cell proliferation. Mutations in this gene are associated with the growth of certain tumors. Pseudogenes of this gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010] |
| UniProt Code: | P62070 |
| NCBI GenInfo Identifier: | 49065833 |
| NCBI Gene ID: | 22800 |
| NCBI Accession: | P62070.1 |
| UniProt Secondary Accession: | P62070,P17082, B2R9Z3, B7Z5Z2, B7Z6C4, B7Z7H6, |
| UniProt Related Accession: | P62070 |
| Molecular Weight: | 204 |
| NCBI Full Name: | Ras-related protein R-Ras2 |
| NCBI Synonym Full Names: | related RAS viral (r-ras) oncogene homolog 2 |
| NCBI Official Symbol: | RRAS2 |
| NCBI Official Synonym Symbols: | TC21 |
| NCBI Protein Information: | ras-related protein R-Ras2; ras-like protein TC21; teratocarcinoma oncogene |
| UniProt Protein Name: | Ras-related protein R-Ras2 |
| UniProt Synonym Protein Names: | Ras-like protein TC21; Teratocarcinoma oncogene |
| Protein Family: | Ras-related protein |
| UniProt Gene Name: | RRAS2 |
| UniProt Entry Name: | RRAS2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RRAS2 antibody (CAB7076) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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