Anti-RPS24 Antibody (CAB12123)
- SKU:
- CAB12123
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-RPS24 Antibody |
| 抗体コード: | CAB12123 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IP |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human RPS24 (NP_148982.1). |
| 申し込み: | WB IP |
| 推奨希釈: | WB 1:500 - 1:2000 IP 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | U-87MG, 293T, HeLa, Jurkat, Mouse liver, Mouse pancreas, Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human RPS24 (NP_148982.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MNDT VTIR TRKF MTNR LLQR KQMV IDVL HPGK ATVP KTEI REKL AKMY KTTP DVIF VFGF RTHF GGGK TTGF GMIY DSLD YAKK NEPK HRLA RHGL YEKK KTSR KQRK ERKN RMKK VRGT AKAN VGAG KK |
| 遺伝子ID: | 6229 |
| Uniprot: | P62847 |
| セルラーロケーション: | |
| 計算された分子量: | 15kDa/32kDa |
| 観察された分子量: | 19kDa |
| 同義語: | RPS24, DBA3, S24 |
| バックグラウンド: | Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S24E family of ribosomal proteins. It is located in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Mutations in this gene result in Diamond-Blackfan anemia. |
| UniProt Protein Function: | RPS24: Required for processing of pre-rRNA and maturation of 40S ribosomal subunits. Defects in RPS24 are the cause of Diamond-Blackfan anemia type 3 (DBA3). DBA3 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Belongs to the ribosomal protein S24e family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA-binding; Ribosomal; Translation Chromosomal Location of Human Ortholog: 10q22.3 Cellular Component: cytosol; membrane; nucleoplasm; nucleus; small ribosomal subunit Molecular Function:RNA binding; translation initiation factor binding Biological Process: erythrocyte homeostasis; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); mRNA catabolic process, nonsense-mediated decay; ribosomal small subunit biogenesis and assembly; rRNA processing; SRP-dependent cotranslational protein targeting to membrane; translation; translational initiation; viral transcription Disease: Diamond-blackfan Anemia 3 |
| NCBI Summary: | Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S24E family of ribosomal proteins. It is located in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Mutations in this gene result in Diamond-Blackfan anemia. [provided by RefSeq, Nov 2008] |
| UniProt Code: | P62847 |
| NCBI GenInfo Identifier: | 51338645 |
| NCBI Gene ID: | 6229 |
| NCBI Accession: | P62847.1 |
| UniProt Secondary Accession: | P62847,P16632, Q5T0P7, Q5T0P8, Q7Z3D1, E7EPK6, |
| UniProt Related Accession: | P62847 |
| Molecular Weight: | 15kDa |
| NCBI Full Name: | 40S ribosomal protein S24 |
| NCBI Synonym Full Names: | ribosomal protein S24 |
| NCBI Official Symbol: | RPS24 |
| NCBI Official Synonym Symbols: | S24; DBA3 |
| NCBI Protein Information: | 40S ribosomal protein S24 |
| UniProt Protein Name: | 40S ribosomal protein S24 |
| UniProt Synonym Protein Names: | Small ribosomal subunit protein eS24 |
| Protein Family: | 40S ribosomal protein |
| UniProt Gene Name: | RPS24 |
 | Western blot analysis of extracts of various cell lines, using RPS24 antibody (CAB12123) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunoprecipitation analysis of 200ug extracts of HeLa cells using 3ug RPS24 antibody ( A12123). Western blot was performed from the immunoprecipitate using RPS24 antibody ( A12123) at a dilition of 1:1000. |
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