| UniProt Protein Function: | RFA2: Required for DNA recombination, repair and replication. The activity of RP-A is mediated by single-stranded DNA binding and protein interactions. Required for the efficient recruitment of the DNA double-strand break repair factor RAD51 to chromatin in response to DNA damage. Heterotrimer of 70, 32 and 14 kDa chains (canonical replication protein A complex). Component of the alternative replication protein A complex (aRPA) composed of RPA1, RPA3 and RPA4. The DNA-binding activity may reside exclusively on the 70 kDa subunit. Binds to SERTAD3/RBT1. Interacts with TIPIN. Directly interacts with PPP4R2, but not with SMEK2; this interaction is DNA damage-dependent and leads RPA2 dephosphorylation by PPP4C recruitment. Interacts with RAD51, preferentially when hyperphosphorylated. Directly interacts with RFWD3. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA replication Chromosomal Location of Human Ortholog: 1p35 Cellular Component: chromatin; chromosome, telomeric region; DNA replication factor A complex; nuclear chromosome, telomeric region; nucleoplasm; nucleus; PML body Molecular Function:damaged DNA binding; enzyme binding; protein binding; protein N-terminus binding; protein phosphatase binding; single-stranded DNA binding; ubiquitin protein ligase binding Biological Process: base-excision repair; bypass DNA synthesis; DNA damage response, detection of DNA damage; DNA repair; DNA replication; DNA strand elongation during DNA replication; double-strand break repair; double-strand break repair via homologous recombination; error-prone postreplication DNA repair; G1 DNA damage checkpoint; G1/S transition of mitotic cell cycle; mismatch repair; mitotic cell cycle; nucleotide-excision repair; nucleotide-excision repair, DNA gap filling; nucleotide-excision repair, DNA incision; telomere maintenance; telomere maintenance via recombination; telomere maintenance via semi-conservative replication; transcription-coupled nucleotide-excision repair |
| UniProt Code: | P15927 |
| NCBI GenInfo Identifier: | 132474 |
| NCBI Gene ID: | 6118 |
| NCBI Accession: | P15927.1 |
| UniProt Secondary Accession: | P15927,Q52II0, Q5TEI9, Q5TEJ5, |
| UniProt Related Accession: | P15927 |
| Molecular Weight: | 38,810 Da |
| NCBI Full Name: | Replication protein A 32 kDa subunit |
| NCBI Synonym Full Names: | replication protein A2 |
| NCBI Official Symbol: | RPA2 |
| NCBI Official Synonym Symbols: | REPA2; RPA32; RP-A p32; RP-A p34 |
| NCBI Protein Information: | replication protein A 32 kDa subunit |
| UniProt Protein Name: | Replication protein A 32 kDa subunit |
| UniProt Synonym Protein Names: | Replication factor A protein 2; RF-A protein 2; Replication protein A 34 kDa subunit; RP-A p34 |
| Protein Family: | Replication protein |
| UniProt Gene Name: | RPA2 |
| UniProt Entry Name: | RFA2_HUMAN |
