Anti-RNF212 Antibody (CAB3569)
- SKU:
- CAB3569
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-RNF212 Antibody |
抗体コード: | CAB3569 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-297 of human RNF212 (NP_001124506.1). |
申し込み: | WB |
推奨希釈: | WB 1:200 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | THP-1, Mouse pancreas, Rat testis |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-297 of human RNF212 (NP_001124506.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MANW VFCN RCFQ PPHR TSCF SLTN CGHV YCDA CLGK GKKN ECLI CKAP CRTV LLSK HTDA DIQA FFMS IDSL CKKY SRET SQIL EFQE KHRK RLLA FYRE KISR LEES LRKS VLQI EQLQ SMRS SQQT AFST IKSS VSTK PHGC LLPP HSSA PDRL ESME VDLS PSPI RKSE IAAG PARI SMIS PPQD GRMG PHLT ASFC FIPW LTLS KPPV PGEC VISR GSPC FCID VCPH WLLL LAFS SGRH GELT NSKT LPIY AEVQ RAVL FPFQ QAEG TLDT FRTP AVSV VFPL CQFE RKKS F |
遺伝子ID: | 285498 |
Uniprot: | Q495C1 |
セルラーロケーション: | Chromosome, Nucleus |
計算された分子量: | 14kDa/21kDa/26kDa/30kDa/31kDa/33kDa |
観察された分子量: | 37kDa |
同義語: | RNF212, ZHP3 |
バックグラウンド: | This gene encodes a RING finger protein that may function as a ubiquitin ligase. The encoded protein may be involved in meiotic recombination. This gene is located within a linkage disequilibrium block and polymorphisms in this gene may influence recombination rates. Alternate splicing results in multiple transcript variants. |
UniProt Protein Function: | RNF212: SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination. 6 human isoforms produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 6.3.2.-; Ubiquitin conjugating system; SUMO ligase; Ligase Chromosomal Location of Human Ortholog: 4p16.3 Cellular Component: synaptonemal complex Molecular Function:zinc ion binding; ligase activity Biological Process: protein sumoylation; meiotic recombination; meiotic gene conversion; chiasma formation Disease: Recombination Rate Quantitative Trait Locus 1 |
NCBI Summary: | This gene encodes a RING finger protein that may function as a ubiquitin ligase. The encoded protein may be involved in meiotic recombination. This gene is located within a linkage disequilibrium block and polymorphisms in this gene may influence recombination rates. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010] |
UniProt Code: | Q495C1 |
NCBI GenInfo Identifier: | 121943260 |
NCBI Gene ID: | 285498 |
NCBI Accession: | Q495C1.1 |
UniProt Secondary Accession: | Q495C1,Q495C0, Q86W82, Q8IY99, Q8N8U7, C9J8N0, |
UniProt Related Accession: | Q495C1 |
Molecular Weight: | 297 |
NCBI Full Name: | Probable E3 SUMO-protein ligase RNF212 |
NCBI Synonym Full Names: | ring finger protein 212 |
NCBI Official Symbol: | RNF212 |
NCBI Official Synonym Symbols: | ZHP3 |
NCBI Protein Information: | probable E3 SUMO-protein ligase RNF212 |
UniProt Protein Name: | Probable E3 SUMO-protein ligase RNF212 |
UniProt Synonym Protein Names: | RING finger protein 212 |
Protein Family: | Probable E3 SUMO-protein ligase |
UniProt Gene Name: | RNF212 |
UniProt Entry Name: | RN212_HUMAN |
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