Anti-RNF128 Antibody (CAB18276)
- SKU:
- CAB18276
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| 抗体名: | Anti-RNF128 Antibody |
| 抗体コード: | CAB18276 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human RNF128. |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | Recombinant protein of human RNF128. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 79589 |
| Uniprot: | Q8TEB7 |
| セルラーロケーション: | |
| 計算された分子量: | 46kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | GRAIL, RNF128 |
| バックグラウンド: | The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. |
| UniProt Protein Function: | RNF128: E3 ubiquitin-protein ligase that catalyzes polyubiquitin chains. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription and this activity is likely to be mediated by E3 ligase activity. Plays an important role in the induction of the anergic phenotype. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural- inducing signals. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 6.3.2.19; EC 6.3.2.-; Ligase; Membrane protein, integral; Ubiquitin ligase; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: Xq22.3 Molecular Function:protein binding Biological Process: regulation of protein stability |
| NCBI Summary: | The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8TEB7 |
| NCBI GenInfo Identifier: | 74751443 |
| NCBI Gene ID: | 79589 |
| NCBI Accession: | Q8TEB7.1 |
| UniProt Secondary Accession: | Q8TEB7,Q6PH80, Q6ZTJ8, Q96RF3, Q9H5E4, A0PJI4, |
| UniProt Related Accession: | Q8TEB7 |
| Molecular Weight: | 44,617 Da |
| NCBI Full Name: | E3 ubiquitin-protein ligase RNF128 |
| NCBI Synonym Full Names: | ring finger protein 128, E3 ubiquitin protein ligase |
| NCBI Official Symbol: | RNF128 |
| NCBI Official Synonym Symbols: | GRAIL |
| NCBI Protein Information: | E3 ubiquitin-protein ligase RNF128 |
| UniProt Protein Name: | E3 ubiquitin-protein ligase RNF128 |
| UniProt Synonym Protein Names: | Gene related to anergy in lymphocytes protein; GRAIL; RING finger protein 128 |
| Protein Family: | E3 ubiquitin-protein ligase |
| UniProt Gene Name: | RNF128 |
| UniProt Entry Name: | RN128_HUMAN |