Anti-RNASE3 Antibody (CAB14489)
- SKU:
- CAB14489
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-RNASE3 Antibody |
| 抗体コード: | CAB14489 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human RNASE3 (NP_002926.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Rat |
| ポジティブサンプル: | K-562, Rat liver, Rat lung |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human RNASE3 (NP_002926.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | RSRF RVPL LHCD LINP GAQN ISNC TYAD RPGR RFYV VACD NRDP RDSP RYPV VPVH LDTT I |
| 遺伝子ID: | 6037 |
| Uniprot: | P12724 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 18kDa |
| 観察された分子量: | 16KDa |
| 同義語: | RNASE3, ECP, RAF1, RNS3 |
| バックグラウンド: | The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria |
| UniProt Protein Function: | RNASE3: Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content. Belongs to the pancreatic ribonuclease family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; EC 3.1.27.-; Ribonuclease Chromosomal Location of Human Ortholog: 14q11.2 Cellular Component: extracellular space; extracellular region Molecular Function:nucleic acid binding; endonuclease activity; ribonuclease activity Biological Process: defense response to Gram-positive bacterium; innate immune response in mucosa; RNA catabolic process; antibacterial humoral response |
| NCBI Summary: | The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria [provided by RefSeq, Oct 2014] |
| UniProt Code: | P12724 |
| NCBI GenInfo Identifier: | 147744558 |
| NCBI Gene ID: | 6037 |
| NCBI Accession: | P12724.2 |
| UniProt Secondary Accession: | P12724,Q4VBC1, Q8WTP7, Q8WZ62, Q9GZN9, |
| UniProt Related Accession: | P12724 |
| Molecular Weight: | 18kDa |
| NCBI Full Name: | Eosinophil cationic protein |
| NCBI Synonym Full Names: | ribonuclease, RNase A family, 3 |
| NCBI Official Symbol: | RNASE3 |
| NCBI Official Synonym Symbols: | ECP; RNS3 |
| NCBI Protein Information: | eosinophil cationic protein; RNase 3; ribonuclease 3; cytotoxic ribonuclease |
| UniProt Protein Name: | Eosinophil cationic protein |
| UniProt Synonym Protein Names: | Ribonuclease 3; RNase 3 |
| Protein Family: | Eosinophil cationic protein |
| UniProt Gene Name: | RNASE3 |
| UniProt Entry Name: | ECP_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RNASE3 antibody (CAB14489) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 180s. |
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