Anti-RHOA/RHOB/RHOC Antibody (CAB4855)
- SKU:
- CAB4855
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ARH9
- Synonyms:
- ARHC
- Synonyms:
- H9
- Synonyms:
- RHOH9
Frequently bought together:
Description
| 抗体名: | RHOA/RHOB/RHOC Rabbit mAb |
| 抗体コード: | CAB4855 |
| サイズ: | 20uL, 50uL, 100uL |
| 同義語: | ARH9, ARHC, H9, RHOH9 |
| 申し込み: | WB, IHC, IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthesized peptide derived from human RHOA/RHOB/RHOC |
| 申し込み: | WB, IHC, IF |
| 推奨される希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa, MCF7, NIH/3T3, SH-SY5Y, HUVEC, Mouse brain, Mouse kidney, Rat brain |
| 免疫原: | A synthesized peptide derived from human RHOA/RHOB/RHOC |
| 精製方法: | Affinity purification |
| 保管所: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 389/387/388 |
| Uniprot: | P08134/P61586/P62745 |
| 計算された分子量: | 22kDa |
| 観察された分子量: | 22KDa |
| UniProt Protein Function: | RHOC: a small G protein of the Rho family. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Controls the reorganization of actins into podosomes. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. |
| UniProt Protein Details: | Protein type:G protein, monomeric; Motility/polarity/chemotaxis; G protein, monomeric, Rho; G protein Chromosomal Location of Human Ortholog: 1p13.1 Cellular Component: cleavage furrow; cytosol; plasma membrane Molecular Function:protein binding; signal transducer activity Biological Process: apical junction assembly; cytokinesis; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of lipase activity; regulation of small GTPase mediated signal transduction |
| NCBI Summary: | This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P08134 |
| NCBI GenInfo Identifier: | 132543 |
| NCBI Gene ID: | 389 |
| NCBI Accession: | P08134.1 |
| UniProt Secondary Accession: | P08134,Q6ICN3, B3KSW1, |
| UniProt Related Accession: | P08134 |
| Molecular Weight: | 22,006 Da |
| NCBI Full Name: | Rho-related GTP-binding protein RhoC |
| NCBI Synonym Full Names: | ras homolog family member C |
| NCBI Official Symbol: | RHOC |
| NCBI Official Synonym Symbols: | H9; ARH9; ARHC; RHOH9 |
| NCBI Protein Information: | rho-related GTP-binding protein RhoC |
| UniProt Protein Name: | Rho-related GTP-binding protein RhoC |
| UniProt Synonym Protein Names: | Rho cDNA clone 9; h9 |
| Protein Family: | Rho-related GTP-binding protein |
| UniProt Gene Name: | RHOC |
| UniProt Entry Name: | RHOC_HUMAN |