Anti-RGS8 Antibody (CAB9987)
- SKU:
- CAB9987
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-RGS8 Antibody |
| 抗体コード: | CAB9987 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human RGS8 (NP_001095920.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | SH-SY5Y, Jurkat, Mouse brain, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human RGS8 (NP_001095920.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAAL LMPR RNKG MRTR LGCL SHKS DSCS DFTA ILPD KPNR ALKR LSTE EATR WADS FDVL LSHK YGVA AFRA FLKT EFSE ENLE FWLA CEEF KKTR STAK LVSK AHRI FEEF VDVQ APRE VNID FQTR EATR KNLQ EPSL TCFD QAQG KVHS LMEK DSYP RFLR SKMY LDLL SQSQ RRLS |
| 遺伝子ID: | 85397 |
| Uniprot: | P57771 |
| セルラーロケーション: | |
| 計算された分子量: | 20kDa/22kDa |
| 観察された分子量: | 17kDa/20kDa |
| 同義語: | RGS8 |
| バックグラウンド: | This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation. |
| UniProt Protein Function: | Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:18434541). Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling. |
| NCBI Summary: | This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P57771 |
| NCBI GenInfo Identifier: | 13124465 |
| NCBI Gene ID: | 85397 |
| NCBI Accession: | P57771.1 |
| UniProt Secondary Accession: | P57771,Q3SYD2, B4DGL9, |
| UniProt Related Accession: | P57771 |
| Molecular Weight: | 22,970 Da |
| NCBI Full Name: | Regulator of G-protein signaling 8 |
| NCBI Synonym Full Names: | regulator of G-protein signaling 8 |
| NCBI Official Symbol: | RGS8 |
| NCBI Protein Information: | regulator of G-protein signaling 8 |
| UniProt Protein Name: | Regulator of G-protein signaling 8 |
| Protein Family: | Regulator of G-protein signaling |
| UniProt Gene Name: | RGS8 |
| UniProt Entry Name: | RGS8_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RGS8 antibody (CAB9987) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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