Anti-RGS3 Antibody (CAB6719)
- SKU:
- CAB6719
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-RGS3 Antibody |
| 抗体コード: | CAB6719 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human RGS3 (NP_570613.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | U-251MG |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human RGS3 (NP_570613.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MNRF NGLC KVCS ERRY RQIT IPRG KDGF GFTI CCDS PVRV QAVD SGGP AERA GLQQ LDTV LQLN ERPV EHWK CVEL AHEI RSCP SEII LLVW RMVP QVKP GPDG GVLR RASC KSTH DLQS PPNK REKN CTHG VQAR PEQR HSCH LVCD SSDG LLLG GWER YTEV AKRG GQHT LPAL SRAT APTD PNYI ILAP LNPG SQLL RPVY QEDT IPEE SGSP SKGK SYTG LGKK SRLM KTVQ TMKG HGNY QNCP VVRP HATH SSYG TYVT LAPK VL |
| 遺伝子ID: | 5998 |
| Uniprot: | P49796 |
| セルラーロケーション: | Cell membrane, Cytoplasm, Nucleus, Peripheral membrane protein |
| 計算された分子量: | 23-36kDa/56-67kDa/100-132kDa |
| 観察された分子量: | 100kDa |
| 同義語: | RGS3, C2PA, RGP3 |
| バックグラウンド: | This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear. |
| UniProt Protein Function: | RGS3: Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G- protein-mediated release of inositol phosphates and activation of MAP kinases. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GAPs; GAPs, RGS Chromosomal Location of Human Ortholog: 9q32 Cellular Component: cytoplasm; cytosol; nucleoplasm; plasma membrane Molecular Function:GTPase activator activity; protein binding Biological Process: inactivation of MAPK activity; regulation of G-protein coupled receptor protein signaling pathway |
| NCBI Summary: | This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTPase-activating protein that inhibits G-protein-mediated signal transduction. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Long isoforms are largely cytosolic and plasma membrane-associated with a function in Wnt signaling and in the epithelial mesenchymal transition, while shorter N-terminally-truncated isoforms can be nuclear. [provided by RefSeq, Jan 2013] |
| UniProt Code: | P49796 |
| NCBI GenInfo Identifier: | 67477383 |
| NCBI Gene ID: | 5998 |
| NCBI Accession: | P49796.2 |
| UniProt Secondary Accession: | P49796,Q5VXB8, Q5VXC1, Q5VZ05, Q5VZ06, Q6ZRM5, Q8IUQ1 Q8NC47, Q8NFN4, A6NHA0, A8K0V1, B3KUB2, |
| UniProt Related Accession: | P49796 |
| Molecular Weight: | 66,478 Da |
| NCBI Full Name: | Regulator of G-protein signaling 3 |
| NCBI Synonym Full Names: | regulator of G-protein signaling 3 |
| NCBI Official Symbol: | RGS3 |
| NCBI Official Synonym Symbols: | C2PA; RGP3 |
| NCBI Protein Information: | regulator of G-protein signaling 3 |
| UniProt Protein Name: | Regulator of G-protein signaling 3 |
| Protein Family: | Regulator of G-protein signaling |
| UniProt Gene Name: | RGS3 |
| UniProt Entry Name: | RGS3_HUMAN |
 | Western blot analysis of extracts of U-251MG cells, using RGS3 antibody (CAB6719) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 5min. |
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