Anti-RGS2 Antibody (CAB1795)
- SKU:
- CAB1795
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| 抗体名: | Anti-RGS2 Antibody |
| 抗体コード: | CAB1795 |
| 抗体サイズ: | 20uL, 50 uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-211 of human RGS2 (NP_002914.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-211 of human RGS2 (NP_002914.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MQSA MFLA VQHD CRPM DKSA GSGH KSEE KREK MKRT LLKD WKTR LSYF LQNS STPG KPKT GKKS KQQA FIKP SPEE AQLW SEAF DELL ASKY GLAA FRAF LKSE FCEE NIEF WLAC EDFK KTKS PQKL SSKA RKIY TDFI EKEA PKEI NIDF QTKT LIAQ NIQE ATSG CFTT AQKR VYSL MENN SYPR FLES EFYQ DLCK KPQI TTEP HAT |
| 遺伝子ID: | 5997 |
| Uniprot: | P41220 |
| セルラーロケーション: | Cell membrane, Cytoplasm, Mitochondrion, Nucleus, nucleolus |
| 計算された分子量: | 20kDa/22kDa/23kDa/24kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | RGS2, G0S8 |
| バックグラウンド: | Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. |
| UniProt Protein Function: | RGS2: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein. 4 isoforms of the human protein are produced by alternative initiation. |
| UniProt Protein Details: | Protein type:Nucleolus; GAPs, misc.; GAPs Chromosomal Location of Human Ortholog: 1q31 Cellular Component: internal side of plasma membrane; neuron projection; mitochondrion; cytoplasm; plasma membrane; nucleolus; cytosol Molecular Function:calmodulin binding; protein binding; beta-tubulin binding; GTPase activator activity Biological Process: regulation of translation; negative regulation of MAP kinase activity; relaxation of vascular smooth muscle; negative regulation of G-protein coupled receptor protein signaling pathway; positive regulation of microtubule polymerization; brown fat cell differentiation; spermatogenesis; cell cycle; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity |
| NCBI Summary: | Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. [provided by RefSeq, Aug 2009] |
| UniProt Code: | P41220 |
| NCBI GenInfo Identifier: | 729545 |
| NCBI Gene ID: | 5997 |
| NCBI Accession: | P41220.1 |
| UniProt Secondary Accession: | P41220,Q6I9U5, |
| UniProt Related Accession: | P41220 |
| Molecular Weight: | 211 |
| NCBI Full Name: | Regulator of G-protein signaling 2 |
| NCBI Synonym Full Names: | regulator of G-protein signaling 2 |
| NCBI Official Symbol: | RGS2 |
| NCBI Official Synonym Symbols: | G0S8 |
| NCBI Protein Information: | regulator of G-protein signaling 2; G0/G1 switch regulatory protein 8; cell growth-inhibiting protein 31; G0 to G1 switch regulatory 8, 24kD; cell growth-inhibiting gene 31 protein; regulator of G-protein signaling 2, 24kDa |
| UniProt Protein Name: | Regulator of G-protein signaling 2 |
| UniProt Synonym Protein Names: | Cell growth-inhibiting gene 31 protein; G0/G1 switch regulatory protein 8 |
| Protein Family: | Regulator of G-protein signaling |
| UniProt Gene Name: | RGS2 |
| UniProt Entry Name: | RGS2_HUMAN |