Anti-RGS17 Antibody (CAB15815)
- SKU:
- CAB15815
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-RGS17 Antibody |
| 抗体コード: | CAB15815 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 45-130 of human RGS17 (NP_036551.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Mouse brain, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 45-130 of human RGS17 (NP_036551.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | NEER GENA GRPT HTTK MESI QVLE ECQN PTAE EVLS WSQN FDKM MKAP AGRN LFRE FLRT EYSE ENLL FWLA CEDL KKEQ NKKV IE |
| 遺伝子ID: | 26575 |
| Uniprot: | Q9UGC6 |
| セルラーロケーション: | Cytoplasm, Lipid-anchor, Membrane, Nucleus |
| 計算された分子量: | 24kDa |
| 観察された分子量: | 24kDa |
| 同義語: | RGS17, RGS-17, RGSZ2, hRGS17 |
| バックグラウンド: | This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. |
| UniProt Protein Function: | RGS17: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G- protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins. |
| UniProt Protein Details: | Protein type:GAPs; GAPs, RGS Chromosomal Location of Human Ortholog: 6q25.3 Cellular Component: cytoplasm; plasma membrane; nucleus Molecular Function:GTPase activator activity Biological Process: positive regulation of GTPase activity |
| NCBI Summary: | This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UGC6 |
| NCBI GenInfo Identifier: | 21361405 |
| NCBI Gene ID: | 26575 |
| NCBI Accession: | NP_036551 |
| UniProt Secondary Accession: | Q9UGC6,Q5TF49, Q8TD61, Q9UJS8, |
| UniProt Related Accession: | Q9UGC6 |
| Molecular Weight: | 24,359 Da |
| NCBI Full Name: | regulator of G-protein signaling 17 |
| NCBI Synonym Full Names: | regulator of G-protein signaling 17 |
| NCBI Official Symbol: | RGS17 |
| NCBI Official Synonym Symbols: | RGSZ2; RGS-17; hRGS17 |
| NCBI Protein Information: | regulator of G-protein signaling 17 |
| UniProt Protein Name: | Regulator of G-protein signaling 17 |
| Protein Family: | Regulator of G-protein signaling |
| UniProt Gene Name: | RGS17 |
| UniProt Entry Name: | RGS17_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RGS17 antibody (CAB15815) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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