Anti-RFXAP Antibody (CAB9411)
- SKU:
- CAB9411
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-RFXAP Antibody |
| 抗体コード: | CAB9411 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-272 of human RFXAP (NP_000529.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-272 of human RFXAP (NP_000529.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MEAQ GVAE GAGP GAAS GVPH PAAL APAA APTL APAS VAAA ASQF TLLV MQPC AGQD EAAA PGGS VGAG KPVR YLCE GAGD GEEE AGED EADL LDTS DPPG GGES AASL EDLE DEET HSGG EGSS GGAR RRGS GGGS MSKT CTYE GCSE TTSQ VAKQ RKPW MCKK HRNK MYKD KYKK KKSD QALN CGGT ASTG SAGN VKLE ESAD NILS IVKQ RTGS FGDR PARP TLLE QVLN QKRL SLLR SPEV VQFL QKQQ QLLN QQVL EQRQ QQFP GTSM |
| 遺伝子ID: | 5994 |
| Uniprot: | O00287 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 28kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | RFXAP |
| バックグラウンド: | Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated ankyrin-containing protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group D. Transcript variants utilizing different polyA signals have been found for this gene. |
| UniProt Protein Function: | RFXAP: Part of the RFX complex that binds to the X-box of MHC II promoters. Defects in RFXAP are a cause of bare lymphocyte syndrome type 2 (BLS2); also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency. BLS2 is a severe combined immunodeficiency disease with early onset. It is characterized by a profound defect in constitutive and interferon-gamma induced MHC II expression, absence of cellular and humoral T-cell response to antigen challenge, hypogammaglobulinemia and impaired antibody production. The consequence include extreme susceptibility to viral, bacterial and fungal infections. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 13q13.3 Cellular Component: nuclear speck; nucleus Molecular Function:DNA binding; transcription coactivator activity Biological Process: positive regulation of transcription, DNA-dependent Disease: Bare Lymphocyte Syndrome, Type Ii |
| NCBI Summary: | Major histocompatibility (MHC) class II molecules are transmembrane proteins that have a central role in development and control of the immune system. The protein encoded by this gene, along with regulatory factor X-associated ankyrin-containing protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription. Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression. Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group D. Transcript variants utilizing different polyA signals have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O00287 |
| NCBI GenInfo Identifier: | 3287900 |
| NCBI Gene ID: | 5994 |
| NCBI Accession: | O00287.1 |
| UniProt Secondary Accession: | O00287,Q5VZM6, Q8TC40, B2R9T8, |
| UniProt Related Accession: | O00287 |
| Molecular Weight: | 28kDa |
| NCBI Full Name: | Regulatory factor X-associated protein |
| NCBI Synonym Full Names: | regulatory factor X associated protein |
| NCBI Official Symbol: | RFXAP |
| NCBI Protein Information: | regulatory factor X-associated protein |
| UniProt Protein Name: | Regulatory factor X-associated protein |
| UniProt Synonym Protein Names: | RFX DNA-binding complex 36 kDa subunit |
| Protein Family: | Regulatory factor X-associated protein |
| UniProt Gene Name: | RFXAP |
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