| UniProt Protein Function: | RFX2: a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: cytoplasm; nucleus Molecular Function:DNA binding; transcription factor activity Biological Process: acrosome formation; cilium biogenesis; regulation of transcription from RNA polymerase II promoter; spermatid development |
| NCBI Summary: | This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P48378 |
| NCBI GenInfo Identifier: | 254763325 |
| NCBI Gene ID: | 5990 |
| NCBI Accession: | P48378.2 |
| UniProt Secondary Accession: | P48378,Q6IQ44, Q8SNA2, A8K581, B3KNC4, |
| UniProt Related Accession: | P48378 |
| Molecular Weight: | 77,268 Da |
| NCBI Full Name: | DNA-binding protein RFX2 |
| NCBI Synonym Full Names: | regulatory factor X2 |
| NCBI Official Symbol: | RFX2 |
| NCBI Protein Information: | DNA-binding protein RFX2 |
| UniProt Protein Name: | DNA-binding protein RFX2 |
| UniProt Synonym Protein Names: | Regulatory factor X 2 |
| Protein Family: | RFX-like DNA-binding protein |
| UniProt Gene Name: | RFX2 |
| UniProt Entry Name: | RFX2_HUMAN |
