Anti-RFFL Antibody (CAB13604)
- SKU:
- CAB13604
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
| 抗体名: | Anti-RFFL Antibody |
| 抗体コード: | CAB13604 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | IF |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human RFFL (NP_001017368.1). |
| 申し込み: | IF |
| 推奨希釈: | IF 1:50 - 1:200 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human RFFL (NP_001017368.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MWAT CCNW FCLD GQPE EVPP PQGA RMQA YSNP GYSS FPSP TGLE PSCK SCGA HFAN TARK QTCL DCKK NFCM TCSS QVGN GPRL CLLC QRFR ATAF QREE LMKM KVKD LRDY LSLH DIST EMCR EKEE LVLL VLGQ QPVI SQED RTRA STLS PDFP EQQA FLTQ PHSS MVPP TSPN LPSS SAQA TSVP PA |
| 遺伝子ID: | 117584 |
| Uniprot: | Q8WZ73 |
| セルラーロケーション: | Cell membrane, Cytoplasm, Peripheral membrane protein, Recycling endosome membrane, cytosol |
| 計算された分子量: | 36kDa/39kDa/40kDa |
| 観察された分子量: |
| 同義語: | RFFL, CARP-2, CARP2, FRING, RIFIFYLIN, RNF189, RNF34L |
| バックグラウンド: |
| UniProt Protein Function: | RFFL: Has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Vesicle; EC 6.3.2.-; Ubiquitin ligase; Ubiquitin conjugating system; Ligase Chromosomal Location of Human Ortholog: 17q12 Cellular Component: Golgi membrane; membrane; recycling endosome membrane; lysosome; cytoplasmic membrane-bound vesicle; cytoplasm; plasma membrane; endosome membrane; cytosol Molecular Function:protein binding; protease binding; zinc ion binding; p53 binding; ubiquitin protein ligase binding; protein kinase binding; ligase activity Biological Process: ubiquitin-dependent protein catabolic process; intracellular protein transport; proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination during ubiquitin-dependent protein catabolic process; regulation of TOR signaling pathway |
| UniProt Code: | Q8WZ73 |
| NCBI GenInfo Identifier: | 74760639 |
| NCBI Gene ID: | 117584 |
| NCBI Accession: | Q8WZ73.1 |
| UniProt Secondary Accession: | Q8WZ73,Q8NHW0, Q8TBY7, Q96BE6, E1P633, |
| UniProt Related Accession: | Q8WZ73 |
| Molecular Weight: | 363 |
| NCBI Full Name: | E3 ubiquitin-protein ligase rififylin |
| NCBI Synonym Full Names: | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase |
| NCBI Official Symbol: | RFFL |
| NCBI Official Synonym Symbols: | CARP2; FRING; CARP-2; RNF189; RNF34L; RIFIFYLIN |
| NCBI Protein Information: | E3 ubiquitin-protein ligase rififylin; RING finger protein 189; caspase regulator CARP2; FYVE-RING finger protein SAKURA; ring finger and FYVE-like domain containing 1; caspases-8 and -10-associated RING finger protein 2; RING finger and FYVE-like domain-containing protein 1 |
| UniProt Protein Name: | E3 ubiquitin-protein ligase rififylin |
| UniProt Synonym Protein Names: | Caspase regulator CARP2; Caspases-8 and -10-associated RING finger protein 2; CARP-2; FYVE-RING finger protein Sakura; Fring; RING finger and FYVE-like domain-containing protein 1; RING finger protein 189; RING finger protein 34-like |
| Protein Family: | E3 ubiquitin-protein ligase |
| UniProt Gene Name: | RFFL |
| UniProt Entry Name: | RFFL_HUMAN |
 | Immunofluorescence analysis of MCF-7 cells using RFFL antibody (CAB13604). Blue: DAPI for nuclear staining. |
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