Anti-RFC5 Antibody (CAB8056)
- SKU:
- CAB8056
- Product type:
- Antibody
- Application:
- WB
- Application:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | RFC5 Rabbit Polyclonal Antibody |
抗体コード: | CAB8056 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 181-340 of human RFC5 (NP_031396.1). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HeLa, U-251MG, SKOV3, MCF-7, Mouse liver, Mouse spleen |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 181-340 of human RFC5 (NP_031396.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | LMVP RLEH VVEE EKVD ISED GMKA LVTL SSGD MRRA LNIL QSTN MAFG KVTE ETVY TCTG HPLK SDIA NILD WMLN QDFT TAYR NITE LKTL KGLA LHDI LTEI HLFV HRVD FPSS VRIH LLTK MADI EYRL SVGT NEKI QLSS LIAA FQVT RDLI VAEA |
遺伝子ID: | 5985 |
Uniprot: | P40937 |
セルラーロケーション: | Nucleus |
計算された分子量: | 36kDa/38kDa |
観察された分子量: | 38kDa |
同義語: | RFC5, RFC36 |
バックグラウンド: | The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 36 kD subunit. This subunit can interact with the C-terminal region of PCNA. It forms a core complex with the 38 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 9. |
UniProt Protein Function: | RFC5: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. Belongs to the activator 1 small subunits family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 12q24.23 Cellular Component: DNA replication factor C complex; nucleoplasm Molecular Function:DNA clamp loader activity; protein binding; single-stranded DNA-dependent ATPase activity Biological Process: bypass DNA synthesis; DNA damage response, detection of DNA damage; DNA replication; error-prone postreplication DNA repair; nucleotide-excision repair, DNA gap filling; nucleotide-excision repair, DNA incision; nucleotide-excision repair, DNA incision, 5'-to lesion; telomere maintenance via recombination; transcription-coupled nucleotide-excision repair |
NCBI Summary: | The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 36 kD subunit. This subunit can interact with the C-terminal region of PCNA. It forms a core complex with the 38 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 9. [provided by RefSeq, May 2011] |
UniProt Code: | P40937 |
NCBI GenInfo Identifier: | 728777 |
NCBI Gene ID: | 5985 |
NCBI Accession: | P40937.1 |
UniProt Secondary Accession: | P40937,A8MZ62, B3KSX8, |
UniProt Related Accession: | P40937 |
Molecular Weight: | 36,105 Da |
NCBI Full Name: | Replication factor C subunit 5 |
NCBI Synonym Full Names: | replication factor C subunit 5 |
NCBI Official Symbol: | RFC5 |
NCBI Official Synonym Symbols: | RFC36 |
NCBI Protein Information: | replication factor C subunit 5 |
UniProt Protein Name: | Replication factor C subunit 5 |
UniProt Synonym Protein Names: | Activator 1 36 kDa subunit; A1 36 kDa subunit; Activator 1 subunit 5; Replication factor C 36 kDa subunit; RF-C 36 kDa subunit; RFC36 |
Protein Family: | Replication factor |
UniProt Gene Name: | RFC5 |
UniProt Entry Name: | RFC5_HUMAN |
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