Anti-RENBP Antibody (CAB10012)
- SKU:
- CAB10012
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-RENBP Antibody |
| 抗体コード: | CAB10012 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 187-390 of human RENBP (NP_002901.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:1000 |
| 反応性: | Human |
| ポジティブサンプル: | A-549, THP-1 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 187-390 of human RENBP (NP_002901.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | EPMA VPMM LLNL VEQL GEAD EELA GKYA ELGD WCAR RILQ HVQR DGQA VLEN VSEG GKEL PGCL GRQQ NPGH TLEA GWFL LRHC IRKG DPEL RAHV IDKF LLLP FHSG WDPD HGGL FYFQ DADN FCPT QLEW AMKL WWPH SEAM IAFL MGYS DSGD PVLL RLFY QVAE YTFR QFRD PEYG EWFG YLSR EGKV ALSI KGGP FKGC |
| 遺伝子ID: | 5973 |
| Uniprot: | P51606 |
| セルラーロケーション: | |
| 計算された分子量: | 29kDa/48kDa |
| 観察された分子量: | 56kDa |
| 同義語: | RENBP, RBP, RNBP |
| バックグラウンド: | The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature. |
| UniProt Protein Function: | RENBP: Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Belongs to the N-acylglucosamine 2-epimerase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC 5.1.3.8; Inhibitor; Isomerase Chromosomal Location of Human Ortholog: Xq28 Molecular Function:protein homodimerization activity; endopeptidase inhibitor activity; N-acylglucosamine 2-epimerase activity; ATP binding Biological Process: N-acetylneuraminate catabolic process; regulation of blood pressure; N-acetylglucosamine metabolic process; N-acetylmannosamine metabolic process |
| NCBI Summary: | The gene product inhibits renin activity by forming a dimer with renin, a complex known as high molecular weight renin. The encoded protein contains a leucine zipper domain, which is essential for its dimerization with renin. The gene product can catalyze the interconversion of N-acetylglucosamine to N-acetylmannosamine, indicating that it is a GlcNAc 2-epimerase. Transcript variants utilizing alternative promoters have been described in the literature. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P51606 |
| NCBI GenInfo Identifier: | 294862458 |
| NCBI Gene ID: | 5973 |
| NCBI Accession: | P51606.2 |
| UniProt Secondary Accession: | P51606,Q96BI6, B4DNZ3, |
| UniProt Related Accession: | P51606 |
| Molecular Weight: | 29,270 Da |
| NCBI Full Name: | N-acylglucosamine 2-epimerase |
| NCBI Synonym Full Names: | renin binding protein |
| NCBI Official Symbol: | RENBP |
| NCBI Official Synonym Symbols: | RBP; RNBP |
| NCBI Protein Information: | N-acylglucosamine 2-epimerase; AGE; GlcNAc 2-epimerase; N-acetyl-D-glucosamine 2-epimerase |
| UniProt Protein Name: | N-acylglucosamine 2-epimerase |
| UniProt Synonym Protein Names: | GlcNAc 2-epimerase; N-acetyl-D-glucosamine 2-epimerase; Renin-binding protein; RnBP |
| Protein Family: | N-acylglucosamine 2-epimerase |
| UniProt Gene Name: | RENBP |
| UniProt Entry Name: | RENBP_HUMAN |
 | Western blot analysis of extracts of various cell lines, using RENBP antibody (CAB10012) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
View AllClose