Anti-RBM22 Antibody (CAB10025)

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SKU:
CAB10025
Product type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
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Description

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抗体名:Anti-RBM22 Antibody
抗体コード:CAB10025
抗体サイズ:20uL, 50uL, 100uL
申し込み:WB
反応性:Human, Mouse
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human RBM22 (NP_060517.1).
申し込み:WB
推奨希釈:WB 1:500 - 1:2000
反応性:Human, Mouse
ポジティブサンプル:HeLa, MCF7, K-562, SH-SY5Y, 293T
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human RBM22 (NP_060517.1).
精製方法:Affinity purification
ストレージバッファ:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:MATS LGSN TYNR QNWE DADF PILC QTCL GENP YIRM TKEK YGKE CKIC ARPF TVFR WCPG VRMR FKKT EVCQ TCSK LKNV CQTC LLDL EYGL PIQV RDAG LSFK DDMP KSDV NKEY YTQN MERE ISNS DGTR PVGM LGKA TSTS DMLL KLAR TTPY YKRN RPHI CSFW VKGE CKRG EECP YRHE KPTD PDDP LADQ NIKD RYYG INDP VADK LLKR ASTM PRLD PPED KT
遺伝子ID:55696
Uniprot:Q9NW64
セルラーロケーション:Cytoplasm, Nucleus
計算された分子量:41kDa/46kDa
観察された分子量:47kDa
同義語:RBM22, Cwc2, ZC3H16, fSAP47
バックグラウンド:This gene encodes an RNA binding protein. The encoded protein may play a role in cell division and may be involved in pre-mRNA splicing. Related pseudogenes exist on chromosomes 6, 7, 9, 13, 16, 18, and X.
UniProt Protein Function:RBM22: Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses. Belongs to the SLT11 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:RNA-binding; RNA splicing; RNA processing; Spliceosome

Chromosomal Location of Human Ortholog: 5q33.1

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function:calcium-dependent protein binding; nucleocytoplasmic transporter activity; protein binding; U6 snRNA binding

Biological Process: nuclear mRNA cis splicing, via U2-type spliceosome; nuclear mRNA splicing, via spliceosome; positive regulation of RNA splicing; protein import into nucleus, translocation; spliceosomal snRNP biogenesis

NCBI Summary:This gene encodes an RNA binding protein. The encoded protein may play a role in cell division and may be involved in pre-mRNA splicing. Related pseudogenes exist on chromosomes 6, 7, 9, 13, 16, 18, and X. [provided by RefSeq, Mar 2009]
UniProt Code:Q9NW64
NCBI GenInfo Identifier:74762758
NCBI Gene ID:55696
NCBI Accession:Q9NW64.1
UniProt Secondary Accession:Q9NW64,O95607, A6NDM5, B4DLI9,
UniProt Related Accession:Q9NW64
Molecular Weight:41,152 Da
NCBI Full Name:Pre-mRNA-splicing factor RBM22
NCBI Synonym Full Names:RNA binding motif protein 22
NCBI Official Symbol:RBM22  
NCBI Official Synonym Symbols:Cwc2; ZC3H16; fSAP47  
NCBI Protein Information:pre-mRNA-splicing factor RBM22
UniProt Protein Name:Pre-mRNA-splicing factor RBM22
UniProt Synonym Protein Names:RNA-binding motif protein 22; Zinc finger CCCH domain-containing protein 16
Protein Family:Pre-mRNA-splicing factor
UniProt Gene Name:RBM22  
UniProt Entry Name:RBM22_HUMAN
Anti-RBM22 Antibody (CAB10025)Western blot analysis of extracts of various cell lines, using RBM22 antibody (CAB10025) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
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