Anti-RBM15 Antibody (CAB4936)
- SKU:
- CAB4936
- Product type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- RBM15
- Synonyms:
- OTT
- Synonyms:
- OTT1
- Synonyms:
- SPEN
Frequently bought together:
Description
抗体名: | RBM15 Rabbit pAb |
抗体コード: | CAB4936 |
サイズ: | 20uL, 50uL, 100uL |
同義語: | RBM15, OTT, OTT1, SPEN |
申し込み: | WB, IHC |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 530-780 of human RBM15 (NP_001188474.1). |
申し込み: | WB, IHC |
推奨される希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
反応性: | Human, Mouse |
ポジティブサンプル: | HL-60, HepG2 |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 530-780 of human RBM15 (NP_001188474.1). |
精製方法: | Affinity purification |
保管所: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | EHRY QQQY LQPL PLTH YELV TDAF GHRA PDPL RGAR DRTP PLLY RDRD RDLY PDSD WVPP PPPV RERS TRTA ATSV PAYE PLDS LDRR RDGW SLDR DRGD RDLP SSRD QPRK RRLP EESG GRHL DRSP ESDR PRKR HCAP SPDR SPEL SSSR DRYN SDND RSSR LLLE RPSP IRDR RGSL EKSQ GDKR DRKN SASA ERDR KHRT TAPT EGKS PLKK EDRS DGSA PSTS TASS KLKS PSQK QDGG TAPV ASA |
遺伝子ID: | 64783 |
Uniprot: | Q96T37 |
セルラーロケーション: | Nucleus, Nucleus membrane, Nucleus speckle, Peripheral membrane protein, nucleoplasm |
計算された分子量: | 99kDa/104kDa/106kDa/107kDa |
観察された分子量: | 120kDa |
UniProt Protein Function: | RBM15: May be implicated in HOX gene regulation. A chromosomal aberration involving RBM15 may be a cause of acute megakaryoblastic leukemia. Translocation t(1;22)(p13;q13) with MKL1. Although both reciprocal fusion transcripts are detected in acute megakaryoblastic leukemia (AMKL, FAB-M7), the RBM15-MKL1 chimeric protein has all the putative functional domains encoded by each gene and is the candidate oncogene. Belongs to the RRM Spen family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Spliceosome; Oncoprotein; RNA-binding Chromosomal Location of Human Ortholog: 1p13 Cellular Component: nucleoplasm; nuclear membrane Molecular Function:protein binding; nucleotide binding Biological Process: spleen development; patterning of blood vessels; negative regulation of myeloid cell differentiation; viral reproduction; negative regulation of transcription, DNA-dependent; activation of Notch receptor target transcription factor |
NCBI Summary: | Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009] |
UniProt Code: | Q96T37 |
NCBI GenInfo Identifier: | 32363506 |
NCBI Gene ID: | 64783 |
NCBI Accession: | Q96T37.2 |
UniProt Secondary Accession: | Q96T37,Q3ZB86, Q4V760, Q5D058, Q5T613, Q86VW9, Q96PE4 Q96SC5, Q96SC6, Q96SC9, Q96SD0, A1A693, |
UniProt Related Accession: | Q96T37 |
Molecular Weight: | 977 |
NCBI Full Name: | Putative RNA-binding protein 15 |
NCBI Synonym Full Names: | RNA binding motif protein 15 |
NCBI Official Symbol: | RBM15 |
NCBI Official Synonym Symbols: | OTT; OTT1; SPEN |
NCBI Protein Information: | putative RNA-binding protein 15; one twenty-two; one twenty two protein; one-twenty two protein 1; RNA-binding motif protein 15 |
UniProt Protein Name: | Putative RNA-binding protein 15 |
UniProt Synonym Protein Names: | One-twenty two protein 1; RNA-binding motif protein 15 |
Protein Family: | Putative RNA-binding protein |
UniProt Gene Name: | RBM15 |
UniProt Entry Name: | RBM15_HUMAN |